Ehlers-Danlos Syndrome

Title: Ehlers-Danlos SyndromeCategory: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 8/30/2018 12:00:00 AM
Source: MedicineNet Arthritis General - Category: Rheumatology Source Type: news

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AbstractCIA is a well-studied animal model of autoimmune arthritis. It resembles rheumatoid arthritis as far as histopathological changes and molecular pathogenesis are concerned. CIA is induced by immunization with collagen type II in susceptible strains. The purpose of this review is to assess the use of CIA animal model on bone metabolism and the potential therapeutic agents that could reverse this effect. A database search from their inception to 2019 was conducted to identify experimental animal studies pertinent to CIA model and bone examination. Studies including ovariectomy or without a direct comparison between co...
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research
Authors: Breahna A, Mishra A, Arrowsmith J, Lindau T Abstract A systematic review was conducted to identify the best management for acute proximal interphalangeal joint fracture-dislocations. A study protocol was designed in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Due to limited data in the primary assessment, the hypothesis was tested in a secondary analysis of articles that marginally met the inclusion criteria (i.e. studies that included patients under 18 years of age). A further tertiary analysis was conducted by dividing the studies into closed reducti...
Source: Journal of Plastic Surgery and Hand Surgery - Category: Surgery Tags: J Plast Surg Hand Surg Source Type: research
WEDNESDAY, July 8, 2020 -- Upadacitinib monotherapy results in improved outcomes versus methotrexate for patients with predominantly early rheumatoid arthritis, according to a study published online July 8 in Arthritis&Rheumatology. Ronald van...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Researchers here show that declining cortisol levels cause macrophage cells of the innate immune system to become more inflammatory with age. This contributes to the state of chronic inflammation in older individuals that accelerates the onset and progression of age-related disease. The aging immune system becomes overactive (inflammaging) and less capable (immunosenescence), and its chronic inflammation acts to disrupt tissue maintenance and cell behavior in numerous harmful ways. Loss of cortisol is only a proximate cause of chronic inflammation, however, and the present research says little of how this relates to deeper...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
This report describes a case of tenosynovitis with psammomatous calcification treated with excision of the mass from the flexor digitorum superficialis tendon and release of both the A1 and palmar aponeurosis pulleys in an adolescent patient. [Orthopedics. 201x; xx(x):xx-xx.]. PMID: 28530766 [PubMed - as supplied by publisher]
Source: Orthopedics - Category: Orthopaedics Authors: Tags: Orthopedics Source Type: research
Abstract Introduction: Lowered pressure pain thresholds have been demonstrated in adults with Ehlers‐Danlos Hypermobility type(EDS‐HT), however it remains unclear if these findings are also present in children. Therefore, the objectives of the study were to: (1)determine if generalized hyperalgesia is present in Hypermobility syndrome (HMS)/EDS‐HT children, (2)explore potential differences in pressure pain thresholds between HMS/EDS‐HT children and adults, and (3)determine the discriminative value of generalized hyperalgesia. Methods: Patients classified in one of three groups: HMS/EDS‐HT, hypermobile (Beighton s...
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Original Article Source Type: research
Psoriatic arthritis can be a debilitating condition. It can lead to painful complications such as neuropathy. Its treatments can lead to complications such as shingles, which can leave a patient with continuing pain. Ehlers-Danlos Syndrome is for most patients a painful condition that leads to spontaneous dislocations, early arthritis, and frequent migraines. My husband and I have decades of experience between us in living with these conditions. My husband and I are also physicians with 57 years experience working with patients between us. We have a world of inside information from both sides of the aisle on the chronic pa...
Source: Kevin, M.D. - Medical Weblog - Category: Journals (General) Authors: Tags: Meds Pain management Source Type: blogs
Swan neck deformity, or hyperextension of the proximal interphalangeal joint, may occur secondary to trauma, rheumatoid arthritis, cerebral palsy, or Ehlers-Danlos syndrome, and can be treated with tenodesis of one slip of the flexor digitorum sublimis tendon. This technique has several variations, differing primarily in the specific location and method that a single slip of the flexor digitorum sublimis tendon is secured, but they all serve to create a static volar restraint against hyperextension.
Source: The Journal of Hand Surgery - Category: Surgery Authors: Tags: Surgical technique Source Type: research
Swan neck deformity, or hyperextension of the proximal interphalangeal joint, may occur secondary to trauma, rheumatoid arthritis, cerebral palsy, or Ehlers-Danlos syndrome, and can be treated with tenodesis of one slip of the flexor digitorum sublimis tendon. This technique has several variations, differing primarily in the specific location and method that a single slip of the flexor digitorum sublimis tendon is secured, but they all serve to create a static volar restraint against hyperextension.
Source: The Journal of Hand Surgery - Category: Surgery Authors: Tags: Surgical technique Source Type: research
This article focuses on reconstruction of the ligamentum teres (LT) of the hip using a tibialis anterior allograft to treat severe instability and pain in a 43 year-old female with EDS. The LT reconstruction was accompanied by labral repair and capsular plication. The patient was assessed pre- and postoperatively using modified Harris Hip Score (mHHS), Hip Outcome Score Activities of Daily Living (HOS-ADLS), Hip Outcome Score Sports Specific Subscale (HOS-SSS), Non Arthritic Hip Score (NAHS), Visual Analog Scale (VAS), and satisfaction. One year following surgery the patient has reported positive outcomes in terms of pain ...
Source: Hip International - Category: Orthopaedics Authors: Tags: Hip Int Source Type: research
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