Response to Comment on "Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water"

Best et al. claim that we provide no convincing basis to assert that a discrepancy remains between FRET and SAXS results on the dimensions of disordered proteins under physiological conditions. We maintain that a clear discrepancy is apparent in our and other recent publications, including results shown in the Best et al. comment. A plausible origin is fluorophore interactions in FRET experiments.

Source: ScienceNOW - August 30, 2018 Category: Science Authors: Riback, J. A., Bowman, M. A., Zmyslowski, A., Knoverek, C. R., Jumper, J., Kaye, E. B., Freed, K. F., Clark, P. L., Sosnick, T. R. Tags: Biochemistry t-comment Source Type: news