Fetal —not Maternal—APOL1 Genotype Associated with Risk for Preeclampsia in Those with African Ancestry

Black Americans are at increased risk for preeclampsia. Genetic variants in apolipoprotein L1 (APOL1) account for much of the increased risk for kidney disease in blacks. APOL1 is expressed in human placenta and transgenic mice expressing APOL1 develop preeclampsia. We evaluated the role of APOL1 variants in human preeclampsia. We determined maternal and fetal APOL1 genotypes in black women with preeclampsia in two populations. At Einstein Montefiore Center (EMC) Affiliated Hospitals, we studied 121 pregnancies in black women with preeclampsia.

Source: The American Journal of Human Genetics - August 30, 2018 Category: Genetics & Stem Cells Authors: Kimberly J. Reidy, Rebecca C. Hjorten, Claire L. Simpson, Avi Z. Rosenberg, Stacy D. Rosenblum, Csaba P. Kovesdy, Frances A. Tylavsky, Joseph Myrie, Bianca L. Ruiz, Soulin Haque, Khyobeni Mozhui, George W. Nelson, Victor A. David, Xiaoping Yang, Masako Su Tags: Article Source Type: research