Risk Factors of Early Recurrence in Retroperitoneal Liposarcoma

ConclusionsThis study underlines the crucial role aggressive surgical approach in retroperitoneal Liposarcoma treatment, especially in those patients with histological characteristics that adversely the prognosis.ResumenIntroducciónEl objetivo de este estudio consistió en identificar los factores asociados a la recurrencia y supervivencia del liposarcoma retroperitoneal primario.MétodosSe analizó retrospectivamente una base de datos prospectiva de 35 pacientes con liposarcoma retroperitoneal primario tratados quirúrgicamente entre 2004-2015. Los criterios de exclusión fueron tumores recurrentes y metastásicos. Se analizó la supervivencia global (SG) y la supervivencia libre de enfermedad. Los datos de los pacientes se compararon entre los pacientes con o sin recurrencia dentro de los 12 meses posteriores a la cirugía. Los factores de riesgo se determinaron mediante análisis de regresión logística.ResultadosLa SG a los 5 años fue del 61,1%. La supervivencia libre de enfermedad al año y a los 3 años fue del 68,6% al año y del 17,1% respectivamente. La SG en el grupo con recurrencia precoz fue del 36,4% a los 5 años frente al 71,3% en el grupo sin recurrencia precoz (p = 0,011). La recurrencia precoz se asoció a una disminución de la SG (HR = 4,05; IC95%: 1,27-12,96; p = 0,018). La multifocalidad y márgenes quir...
Source: Cirugia Espanola - Category: Surgery Source Type: research

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Publication date: Available online 10 November 2019Source: Seminars in Cancer BiologyAuthor(s): Jessica Burns, Christopher P Wilding, Robin L Jones, Paul H HuangAbstractSarcomas are a rare group of mesenchymal cancers comprising over 70 different histological subtypes. For the majority of these diseases, the molecular understanding of the basis of their initiation and progression remains unclear. As such, limited clinical progress in prognosis or therapeutic regimens have been made over the past few decades. Proteomics techniques are being increasingly utilised in the field of sarcoma research. Proteomic research efforts h...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Currently, there is no evidence-based recommendation available regarding the management of lipomas detected during open or laparoscopic inguinal hernia surgery. Due to the extremely low risk of the presence of a liposarcoma routine histologic examination cannot be recommended unless the diameter exceeds 10 cm. PMID: 31690184 [PubMed - as supplied by publisher]
Source: Acta Chirurgica Belgica - Category: Surgery Tags: Acta Chir Belg Source Type: research
ConclusionMedicine cannot provide much care for these advanced cases of multicentric liposarcoma so far. Therefore, more research should be conducted to improve the ability to manage these entities and to identify potential novel therapies.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
The diagnosis of dedifferentiated liposarcoma (DDLPS) is challenging when an atypical lipomatous tumor component is absent or obscure. To analyze the utility and limitations of ancillary techniques, we studied 11 cases of DDLPS in challenging conditions and 17 cases of nonlipogenic high-grade sarcomas with immunohistochemistry (IHC) for p16, CDK4, and MDM2 and automated dual-color in situ hybridization (DISH) for MDM2 amplification. All DDLPS specimens lacked clear lipogenic components and were immunoreactive for p16, CDK4, and MDM2. DISH analyses also revealed high-level amplification of MDM2 in all DDLPS. In contrast, am...
Source: Applied Immunohistochemistry and Molecular Morphology - Category: Chemistry Tags: Research Articles Source Type: research
The purpose of case report was to present a rare case of a solitary metastasis of myxoid liposarcoma and discuss the clinical and pathological information for patients treated for metastatic myxoid liposarcoma.
Source: World Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: Case report Source Type: research
Authors: Seligson ND, Stets CW, Demoret BW, Awasthi A, Grosenbacher N, Shakya R, Hays JL, Chen JL Abstract Dedifferentiated liposarcoma (DDLPS) is a highly morbid mesenchymal tumor characterized and driven by genomic amplification of the MDM2 gene. Direct inhibition of MDM2 has shown promise pre-clinically, but has yet to be validated in clinical trials. Early in vitro studies have demonstrated that pan-histone deacetylase (HDAC) inhibition may have anti-MDM2 effects. Here we present in silico, in vitro, and mouse xenograft studies that suggest that specifically targeting HDAC2 reduces MDM2 expression and has anti-...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Primary retroperitoneal liposarcoma is an extremely rare malignant tumor. Herein, we report a case with an incidentally detected giant retroperitoneal liposarcoma on 68Ga-PSMA PET/CT during primary staging for prostate cancer.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
ConclusionMLL remains to be underdiagnosed. Due to the obesity epidemic, clinicians must be aware of this once rare disease. The role of concurrent bariatric surgery with surgical resection of MLL warrants further studies.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
We report this case to highlight the need for customized surgical oncological measures in the treatment of solid abdominal tumours due to locoregional invasion that usually necessitates en bloc resection.
Source: Journal of Taibah University Medical Sciences - Category: Universities & Medical Training Source Type: research
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Cyrus Parsa, Robert Orlando, Krishna Narayanan, Umakant M. Khetan, Jin Guo, Ravin RupaniAbstractMultiple primary malignancies may occur as synchronous or meta-synchronous tumors in 2–17% of patients. Most multiple primary cancers occur in different locations of the same organ or in other organs such as lung, kidney, prostate, and bone. Occurrence of synchronous colorectal adenocarcinoma with liposarcoma, is exceptionally rare. A 79-year-old male presented with significant weight loss of 2–3 weeks duration following a tra...
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
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