Differentiating responders and non-responders to rTMS treatment for depression after one week using resting EEG connectivity measures

Repetitive transcranial magnetic stimulation (rTMS) is an effective therapy for treatment resistant depression, but in a recent meta-analysis showed low response (29.3%) and remission rates (18.6%) (Berlim  et al., 2014). Typically, rTMS treatments are provided five days per week, often during inpatient admission, making this non-response rate particularly costly for both patients and clinics (George and Post, 2011). Providing clinicians with an ability to predict response is desirable. rTMS treat ment research has indicated that reduction in depression severity from baseline (BL) to endpoint shows a bimodal distribution, suggesting that responders and non-responders reflect categorical groups with distinct responses to rTMS treatment (rather than a continuum of change in response to treatmen t) (Fitzgerald et al., 2016).

Source: Journal of Affective Disorders - August 14, 2018 Category: Neurology Authors: NW Bailey, KE Hoy, NC Rogasch, RH Thomson, S McQueen, D Elliot, CM Sullivan, BD Fulcher, ZJ Daskalakis, PB Fitzgerald Tags: Research paper Source Type: research