Signaling interplay between primary cilia and nitric oxide: A mini review

Publication date: Available online 9 August 2018Source: Nitric OxideAuthor(s): Hannah C. Saternos, Wissam A. AbouAlaiwiAbstractNew discoveries into the functional role of primary cilia are on the rise. In little more than 20 years, research has shown the once vestigial organelle is a signaling powerhouse involved in a vast number of essential cellular processes. In the same decade that interest in primary cilia was burgeoning, nitric oxide won molecule of the year and a Nobel prize for its role as a near ubiquitous signaling molecule. Although primary cilia and nitric oxide are both involved in signaling, a direct relationship has not been investigated; however, after a quick review of the literature, parallels between their functions can be drawn. This review aims to suggest a possible interplay between primary cilia and nitric oxide signaling especially in the areas of vascular tissue homeostasis and cellular proliferation.

Source: Nitric Oxide - August 10, 2018 Category: Chemistry Source Type: research