Recombinant Listeria promotes tumor rejection by CD8+ T cell-dependent remodeling of the tumor microenvironment [Immunology and Inflammation]
Agents that remodel the tumor microenvironment (TME), prime functional tumor-specific T cells, and block inhibitory signaling pathways are essential components of effective immunotherapy. We are evaluating live-attenuated, double-deleted Listeria monocytogenes expressing tumor antigens (LADD-Ag) in the clinic. Here we show in numerous mouse models that while treatment with nonrecombinant LADD...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Weiwen Deng, Victor Lira, Thomas E. Hudson, Edward E. Lemmens, William G. Hanson, Ruben Flores, Gonzalo Barajas, George E. Katibah, Anthony L. Desbien, Peter Lauer, Meredith L. Leong, Daniel A. Portnoy, Thomas W. Dubensky Jr. Tags: Biological Sciences Source Type: research