Zinc depletion induces ribosome hibernation in mycobacteria [Chemistry]

Bacteria respond to zinc starvation by replacing ribosomal proteins that have the zinc-binding CXXC motif (C+) with their zinc-free (C−) paralogues. Consequences of this process beyond zinc homeostasis are unknown. Here, we show that the C− ribosome in Mycobacterium smegmatis is the exclusive target of a bacterial protein Y homolog,...

Source: Proceedings of the National Academy of Sciences - August 7, 2018 Category: Science Authors: Yunlong Li, Manjuli R. Sharma, Ravi K. Koripella, Yong Yang, Prem S. Kaushal, Qishan Lin, Joseph T. Wade, Todd A. Gray, Keith M. Derbyshire, Rajendra K. Agrawal, Anil K. Ojha Tags: Biological Sciences Source Type: research