FDA rejects Pain Therapeutics' lead drug, shares tumble

Pain Therapeutics Inc. is undergoing a major overhaul after the U.S. Food and Drug Administration rejected its new drug application for Remoxy, an extended-release and tamper-resistant version of the painkiller oxycodone. The Austin-based drugmaker said Monday in a securities filing it would shift its focus from painkillers to treatments for Alzheimer's disease. That comes after Pain Therapeutics (Nasdaq: PTIE) heard from the FDA that Remoxy data "do not support the conclusion" that its benefits…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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azzon N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific interest for decades due to its important medical applications. It also represents a nutritional supplement in the human diet. NAC is a glutathione precursor and shows antioxidant and anti-inflammatory activities. In addition to the uses quoted in the literature, NAC may be considered helpful in therapies to counteract neurodegenerative and mental health diseases. Furthermore, this compound has been evaluated for its neuroprotective potential in the prevention of cognitive aging dementia. NAC is inexpensive, commercially avai...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
CONCLUSION: As a potential remediable risk factor, the mechanisms linking pain interference to cognitive decline merit further exploration. PMID: 30543173 [PubMed - as supplied by publisher]
Source: Current Alzheimer Research - Category: Neurology Authors: Tags: Curr Alzheimer Res Source Type: research
This article, however, is more of a commentary on high level strategy and the effects of regulation, coupled with a desire to forge ahead rather than hold back in the matter of treating aging, thus I concur with much more of what is said than is usually the case. For decades, one of the most debated questions in gerontology was whether aging is a disease or the norm. At present, excellent reasoning suggests aging should be defined as a disease - indeed, aging has been referred to as "normal disease." Aging is the sum of all age-related diseases and this sum is the best biomarker of aging. Aging and its d...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Use of moderate and strong opioids is associated with an increased risk of hip fractures in people with Alzheimer ’s disease, according to a study published in PAIN.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Prokineticin 2 (PROK2) is a peptide that is widely distributed in the nervous system and influences a variety of brain functions, such as pain, food intake and circadian rhythms (Negri and Lattanzi, 2012; Negri and Ferrara, 2018). PROK2 is able to mediate its signaling through two different G-protein coupled receptors (GPCR), designated prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2) (Masuda et al., 2002; Soga et al., 2002). They activate multiple intracellular signal-transduction pathways promoting intracellular calcium mobilization (Masuda et al., 2002; Negri and Lattanzi, 2012) by G αq coupling; ...
Source: Neuropeptides - Category: Neuroscience Authors: Source Type: research
(University of Eastern Finland) People using strong painkillers, opioids, have twice the risk of hip fracture compared to non-opioid users, a new study from the University of Eastern Finland shows. The risk was highest in the first two months of opioid use. The results were published in the PAIN journal.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
This study is the culmination of a decade of research that has repeatedly demonstrated that this vaccine can effectively and safely target in animal models what we think may cause Alzheimer's disease. I believe we're getting close to testing this therapy in people." Although earlier research established that antibodies significantly reduce amyloid buildup in the brain, researchers needed to find a safe way to introduce them into the body. A vaccine developed elsewhere showed promise in the early 2000s, but when tested in humans, it caused brain swelling in some patients. The new idea was to start with DNA codin...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Zyluk A, Puchalski P Abstract The case of a patient suffering from Alzheimer's disease who sustained epiphyseal, severely dislocated fractures of the distal radius and ulna is reported. As the patient was incapacitated and attempts to contact her curator failed, the decision was made on a conservative treatment of the fractures. This treatment eventually failed and resulted in malunion with exposure of bone fragments above the skin. After obtaining informed consent from her curator, a corrective osteotomy was performed using an original method, followed by fixation of bone fragments in almost anatomical po...
Source: Handchirurgie Mikrochirurgie Plastische Chirurgie - Category: Cosmetic Surgery Tags: Handchir Mikrochir Plast Chir Source Type: research
Aspirin is best known as an over-the-counter painkiller. But acetylsalicylic acid, as it’s called chemically, has many other health benefits, as well as side effects, in the body that have only become clear in recent years. Here’s what the latest science says about the health benefits and side effects of aspirin, as well as which conditions it may treat and those it doesn’t appear to improve. (If you are taking aspirin for any reason other than for periodic pain relief, it’s best to consult with your doctor to confirm whether the benefits outweigh the risks in your particular case.) How aspirin affe...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Drugs healthytime Source Type: news
Hospice care is designed to bring the highest quality of life to persons that are living with a serious illness, and are often close to death.Bob DeMarcoAlzheimer's Reading RoomThere is a common notion thatHospice helps people die. I don't see it that way.Both of my parents, Frank and Dotty, died at home in their bedroom with the assistance of Hospice by the Sea, Boca Raton, Florida.Hospice did not help my parents to die,they helped them live to the very end of their life with dignity and compassion.Hospice accomplishes their mission of palliative care with a coordinated team of healthcare professionals.Hospice palliative ...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's alzheimer's awareness alzheimer's care alzheimer's dying dementia care elder care family caregiving help alzheimer' s help with dementia care Hospice Care palliative care senior care Source Type: blogs
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