Endoglin targeting in colorectal tumor microenvironment.

Endoglin targeting in colorectal tumor microenvironment.
Clin Cancer Res. 2018 Aug 03;:
Authors: Becker LM, LeBleu VS
Abstract
On endothelial cells, the TGFβ/BMP-9 co-receptor endoglin emerged as a promising anti-angiogenic target in colorectal cancer (CRC). Its promiscuous expression in cancer associated fibroblasts (CAFs) emerges to facilitate metastasis. The multi-target impact of neutralizing endoglin may offer added benefit in controlling CRC.
PMID: 30076135 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - August 3, 2018 Category: Cancer & Oncology Authors: Becker LM, LeBleu VS Tags: Clin Cancer Res Source Type: research