Sequential Payload Release from Acoustically-Responsive Scaffolds Using Focused Ultrasound

Regenerative processes, such as angiogenesis and osteogenesis, often require multiple growth factors with distinct spatiotemporal patterns and expression sequences. Within tissue engineering, hydrogel scaffolds are commonly used for exogenous growth factor delivery. However, direct incorporation of growth factors within conventional hydrogels does not afford spatiotemporally controlled delivery because release is governed by passive mechanisms that cannot be actively controlled after the scaffold is implanted.

Source: Ultrasound in Medicine and Biology - August 2, 2018 Category: Radiology Authors: Alexander Moncion, Melissa Lin, Oliver D. Kripfgans, Renny T. Franceschi, Andrew J. Putnam, Mario L. Fabiilli Tags: Original Contribution Source Type: research