Magnetic Cu0@HAP@γ-Fe2O3 nanoparticles: An efficient catalysts for one-pot three-component reactions for the synthesis of imidazo[1,2-a]pyridines

Publication date: Available online 2 August 2018Source: Journal of Organometallic ChemistryAuthor(s): Wei Sun, Wei Jiang, Gan Zhu, Yiqun LiAbstractCu(0) incorporated magnetic hydroxyapatite nanoparticles (Cu0@HAP@γ-Fe2O3 NPs) was conveniently synthesized via the ion exchange reaction, oxidation, and reduction steps. The structure and composition of the nanohybrid were confirmed by FT-IR, SEM, EDS, TEM, XPS, and TGA. The magnetic Cu0@HAP@γ-Fe2O3 hybrid can efficiently catalyzed a one-pot multicomponent synthesis of imidazo[1,2-a]pyridine derivatives from 2-aminopyridine, aldehyde or glyoxylic acid, and phenylacetylene or alkynyl carboxylic acids in excellent yields. The magnetic nanocatalyst was easily separated from reaction mixture using an external magnet and was successfully examined for three runs with a slight loss of catalytic activity.Graphical abstract
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research