Acral papulovesicular eruption after smallpox vaccination

Smallpox vaccination is associated with several potential cutaneous adverse reactions, ranging from benign self-limited hypersensitivity reactions to life-threatening eczema vaccinatum and progressive vaccinia. Acral papulovesicular eruption is a distinct presentation which has been described in U.S. military members following vaccination with the second generation smallpox vaccine ACAM2000. We characterize this unique eruption with 12 reported cases so far, as well as review previously described cutaneous adverse events associated with smallpox vaccination.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research