Radiation-induced fibrosarcoma in a patient previously irradiated for malignant fibrous histiocytoma

A 59-year-old man presented with a painless 3 cm × 2.5 cm pink nodule with central hemorrhagic crust and surrounding erythema on his right lower leg that had gradually enlarged over the past three years. Notably, the patient had a remote history of malignant fibrous histiocytoma (now undifferentiated pleomorphic sarcoma) of the right distal thigh treated with surgery and radiation. A superficial shave biopsy revealed scar. However, the patient returned two months later complaining that the lesion had enlarged, and a deep shave biopsy demonstrated sheets and fascicles of pleomorphic spindle cells, concerning for sarcoma.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research