Outcome of Pregnancies in Women With Acromegaly Outcome of Pregnancies in Women With Acromegaly

A study of women with acromegaly provides insight into the impact of the disease on maternal-neonatal pregnancy outcomes.Clinical Endocrinology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

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Publication date: 18 April 2019Source: Cell, Volume 177, Issue 3Author(s): Luca A. Lotta, Jacek MokrosiƄski, Edson Mendes de Oliveira, Chen Li, Stephen J. Sharp, Jian’an Luan, Bas Brouwers, Vikram Ayinampudi, Nicholas Bowker, Nicola Kerrison, Vasileios Kaimakis, Diana Hoult, Isobel D. Stewart, Eleanor Wheeler, Felix R. Day, John R.B. Perry, Claudia Langenberg, Nicholas J. Wareham, I. Sadaf FarooqiSummaryThe melanocortin 4 receptor (MC4R) is a G protein-coupled receptor whose disruption causes obesity. We functionally characterized 61 MC4R variants identified in 0.5 million people from UK Biobank and examined their a...
Source: Cell - Category: Cytology Source Type: research
Publication date: Available online 18 April 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Lisa M. ChristianAbstractBirth prior to full term is a substantial public health issue. In the US, ˜400,000 babies per year are born preterm (1 million are early term (37–386/7 weeks). Birth prior to full term confers risk both immediate and long term, including neonatal intensive care, decrements in school performance, and increased mortality risk from infancy through young adulthood. Risk for low birth weight and preterm birth are 1.5-2 times greater among African Americans versus Whites. Psychosocial str...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Discussion: Our findings are consistent with previous observations of increases in lipid mobilisation, coupled with preferential transfer of DHA to the fetus, with advancing gestation. However the number of eligible studies was small and further investigations are required.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research
Authors: Ghoneum MH, Gimzewski JK, Ghoneum AD, Agrawal S Abstract The hydroferrate fluid MRN-100, an iron-based compound with potent antioxidant characteristics, was examined to identify its possible anti-inflammatory effects on human dendritic cells (DCs) in vitro. Human monocyte-derived DCs were treated with MRN-100 at two concentrations (50 and 100 μL/mL) for 24 h and then stimulated with or without lipopolysaccharides (LPS). The expression of DC maturation markers was assessed by flow cytometry and the production of cytokines was determined by enzyme-linked immunosorbent assay (ELISA). Function...
Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research
This study evaluated the effects of HIV infection on nasal carriage of Staphylococcus aureus, staphylococcal peritonitis, and catheter infection rates in patients with end-stage renal failure managed with continuous ambulatory peritoneal dialysis (CAPD). METHODS: Sixty HIV-positive and 59 HIV-negative CAPD patients were enrolled and followed up for up to 18 months. S. aureus nasal carriage (detected by nasal swab culture), Staphylococcal peritonitis (diagnosed by clinical presentation, and CAPD effluent Staphylococcal culture and white blood cell count ≥100 cells/µL), and catheter infections (including ...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
CONCLUSION: sST2 is one of the independent predictors of the no-reflow phenomenon in STEMI patients undergoing primary percutaneous coronary intervention. PMID: 30996145 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Authors: Baik I PMID: 30993941 [PubMed]
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
Authors: Chanson P, Vialon M, Caron P Abstract INTRODUCTION: As pregnancy is rare in women with acromegaly, only case reports and few series have been published. Areas covered: All case reports and publications dealing with pregnancy in patients with acromegaly were collated. Information concerning the effects of acromegaly on pregnancy outcomes, the impact of pregnancy on GH/IGF-I measurements, acromegaly comorbidity and pituitary adenoma size, the effects of treatment of acromegaly on fetus outcomes were retrieved and analyzed. Expert commentary: Based on the small number of reported cases, pregnancy is generally...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
We present a case series of 17 pregnancies in 12 women with acromegaly. 12 women with acromegaly who completed pregnancy were identified from centres involved in the Irish Pituitary Study. 11 women had pituitary macroadenomas, one woman had a microadenoma. Only 5/17 pregnancies had optimal biochemical control of acromegaly pre-conception, as defined by IGF-1 concentration in the age related reference level and plasma GH concentration of
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research
DiscussionPolycystic ovary syndrome (PCOS) affects 6-8% of reproductive-age women making it the most common endocrinopathy in this age group. There is no consensus on the specific diagnostic criteria for PCOS in adolescents as many of the characteristics overlap with normal adolescent physiology. However, patients should have evidence of hyperandrogenism, oligo- or amenorrhea, and potentially polycystic ovaries. PCOS has a genetic component although a specific gene has not been identified. Incidence of PCOS is 20-40% for a woman with a family history. Hyperandrogenism Androgen levels change during puberty therefore actual ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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