FDA approves new pill to reduce pain from endometriosis

US regulators approve new treatment for reducing pain from endometriosis, a common condition that can cause infertility
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news

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Authors: Vassilopoulou L, Matalliotakis M, Zervou MI, Matalliotaki C, Spandidos DA, Matalliotakis I, Goulielmos GN Abstract The aim of the present review was to discuss a matter of concern in the clinical field of obstetrics/gynecology, namely the potency of in vitro fertilization (IVF) in the management of endometriosis-associated infertility. Endometriosis is a medical condition affecting one tenth of women in their fertile years, and accounts for up to 50% of infertile women. Thus, such high prevalence has established the necessity for investigating the effectiveness of available techniques in eradicating the di...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Publication date: Available online 11 August 2018Source: Autoimmunity ReviewsAuthor(s): Tao Zhang, Caterina De Carolis, Man Gene Chi-Wai, Chi-Chiu WangAbstractEndometriosis (EMS), an estrogen-dependent inflammatory disorder affects approximately 5–10% of the general female population of reproductive age and 20–90% of women with pelvic pain and infertility. Many immunological factors are known to contribute significantly to the pathogenesis and pathophysiology of EMS, and both chronic local inflammation and autoantibodies in EMS shares many similarities with autoimmune diseases (AD). However, the autoimmune etio...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Conclusion: Serum caspase-3 level may be a reliable predictor of endometriosis severity.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - Category: OBGYN Source Type: research
ConclusionModerate-to-severe endometriosis was more common in women with East or South East Asian ethnicity in our tertiary referral center. This could be explained by East/South East Asians with minimal-mild disease being less likely to seek care, or genetic/environmental differences that increase the risk of more severe disease amongst East/South East Asians.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Lisa N. Abaid, John S. Cupp, Miles Chang, Steven R. Beanes, Bram H. GoldsteinAbstractEndometriosis is a condition wherein an ectopic layer of endometrial tissue arises in an extra-uterine location, often effecting significant pelvic pain and infertility. While very uncommon, there have been reported cases of endometriosis undergoing malignant transformation, frequently involving the ovaries and seldom in extra-gonadal regions. We recount a case depicting a 63 year-old woman who presented with an apparent inguinal hernia in 2017; she wa...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Publication date: Available online 14 February 2018Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Bansari G. Patel, Emily E. Lenk, Dan I. Lebovic, Yimin Shu, Jie Yu, Robert N. TaylorAbstractDespite an estimated prevalence of 11% in women and plausible historical descriptions dating back to the 17th century, the etiology of endometriosis remains poorly understood. Classical theories of the histological origins of endometriosis are reviewed below. Clinical presentations are variable, and signs and symptoms do not correlate well with the extent of disease. In this summary, we have attempted...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
Publication date: June 2018Source: Best Practice &Research Clinical Endocrinology &Metabolism, Volume 32, Issue 3Author(s): Ioannis Simitsidellis, Douglas A. Gibson, Philippa T.K. SaundersEndometriosis is a chronic incurable disorder that affects 1 in 10 women of reproductive age: associated symptoms include chronic pain and infertility. The aetiology of endometriosis remains poorly understood but patients, clinicians and researchers are all in agreement that new non-surgical therapies are urgently needed to reduce the severity of symptoms. Preclinical testing of drugs requires the development and validation of mod...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Purpose of review Surgery has traditionally been the primary treatment option for endometriosis-related infertility of any phenotype. However, advances and refinements of assisted reproductive technologies (ART) permit a more conservative approach in many scenarios. This review summarizes the latest findings in the field of reproductive medicine, which have supported a paradigm shift towards more conservative management of ovarian endometrioma. Recent findings The presence of ovarian endometrioma per se is likely to impair ovarian reserve and alter ovarian functional anatomy. Conventional laparoscopic surgery is assoc...
Source: Current Opinion in Obstetrics and Gynecology - Category: OBGYN Tags: REPRODUCTIVE ENDOCRINOLOGY: Edited by David L. Olive Source Type: research
Publication date: Available online 14 February 2018Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Bansari G. Patel, Emily E. Lenk, Dan I. Lebovic, Yimin Shu, Jie Yu, Robert N. TaylorAbstractDespite an estimated prevalence of 11% in women and plausible historical descriptions dating back to the 17th century, the etiology of endometriosis remains poorly understood. Classical theories of the histological origins of endometriosis are reviewed below. Clinical presentations are variable, and signs and symptoms do not correlate well with the extent of disease. In this summary, we have attempted...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
ConclusionModerate-to-severe endometriosis was more common in women with East or South East Asian ethnicity in our tertiary referral center. This could be explained by East/South East Asians with minimal-mild disease being less likely to seek care, or genetic/environmental differences that increase the risk of more severe disease amongst East/South East Asians.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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