FDA approves new pill to reduce pain from endometriosis

US regulators approve new treatment for reducing pain from endometriosis, a common condition that can cause infertility
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news

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We present an interesting case of a nulliparous patient that underwent laparoscopic surgery for pelvic endometriosis and 2 years after a laparoscopic excision of an intraligamentous fibroid.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Movies Technique 1 – Surgical techniques in Gynaecology Source Type: research
Introduction: Endometriosis is an enigmatic disease affecting up to 10% of reproductive-aged women causing pain and infertility. Deep infiltrating endometriosis (DIE) is the most severe form of the disease. The impact of surgical treatment for deep endometriosis on fertility success rate of assisted reproduction techniques (ART) is not clear.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Session 24 – Reproductive Medicine Source Type: research
Endometriosis is a common gynecologic condition, affecting approximately 10% of reproductive aged women1-3. It commonly presents with pelvic pain, painful periods, and infertility and can significantly impact one ’s quality of life4-6. Early exploration into the pathophysiology of this condition identified race as a risk factor for endometriosis, with the condition predominantly identified in white women7, 8. It is still unclear if there is biological basis for this conviction, or if it can be explained by methodological and social bias that existed in the literature at that time9-11.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Viewpoint Source Type: research
Abstract MicroRNAs (miRNAs), a class of small non-coding RNA molecules, have been recognized as key post-transcriptional regulators associated with a multitude of human diseases. Global expression profiling studies have uncovered hundreds of miRNAs that are dysregulated in several diseases, and yielded many candidate biomarkers. This review will focus on miRNAs in endometriosis, a common chronic disease affecting nearly 10% of reproductive-aged women, which can cause pelvic pain, infertility, and a myriad of other symptoms. Endometriosis has delayed time-to-diagnosis when compared to other chronic diseases, as the...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
Authors: De Leo V, Cagnacci A, Cappelli V, Biasioli A, Leonardi D, Seracchioli R Abstract Dysmenorrhea and chronic pelvic pain occur in a significantly higher percentage in women with endometriosis; this benign condition has an incidence ranging from 5 to 10% in the general population, while 35% to 50% of infertile women are affected. Treatment of the symptoms demands integrated approaches with the use of anti-inflammatory substances or drugs and lifestyle changes, including attention to diet. The use of traditional anti-inflammatory drugs over the long term is not very successful because of the fear of side effect...
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
Abstract Endometriosis is an important gynecological disease, affecting 10% of reproductive age women, and associated with pain, infertility, reduced quality of life and high health economic cost. Except for ultrasound detection of ovarian endometriotic cysts, the gold standard for diagnosis is laparoscopy, leading to diagnostic delays of 5-10 years. Accurate noninvasive biomarkers are needed, especially for symptomatic women with a normal gynecological ultrasound, to triage them towards medical or surgical treatment and to monitor their treatment outcome. Such biomarkers are not available today, largely because t...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
AbstractEndometriosis is a benign chronic inflammatory disease that mostly affects women of reproductive age. The disease is often associated with dysmenorrhoea, pelvic and non-menstrual pain, and infertility. NSAIDs and hormonal suppression therapies (i.e. estroprogestins and progestins) are generally used as first-line treatment to alleviate pain symptoms. Second-line options include other hormonal suppressants, such as gonadotropin-releasing hormone agonists and antagonists and, less commonly, danazol and aromatase inhibitors.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
Whole exome sequencing identifies hemizygous deletions in the UGT2B28 and USP17L2 genes in a three‑generation family with endometriosis. Mol Med Rep. 2019 Jan 03;: Authors: Albertsen HM, Matalliotaki C, Matalliotakis M, Zervou MI, Matalliotakis I, Spandidos DA, Chettier R, Ward K, Goulielmos GN Abstract Endometriosis is an enigmatic condition with an unknown etiology and a poorly understood pathogenesis. It is considered to appear from the interplay of many genetic and environmental factors, affecting up to 10% of women and represents a major cause of pain and infertility. The familial association of...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
ABSTRACT Introduction: Endometriosis is a chronic gynecological condition characterized by the presence of endometrial tissue in locations outside the uterus. Its symptoms include dysmenorrhea, dyspareunia, chronic pelvic pain, infertility, dysuria, and dyschezia. Several studies have related the vascular endothelial growth factor (VEGF) gene polymorphisms as a factor for the development of endometriosis. Objectives: The aim of this study was to compare the frequency of the VEGF gene polymorphism rs35569394 in women with endometriosis and a control group, as well as to investigate the association of this polymorphism with ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research
Endometriosis is a disease in which tissue that normally grows inside the uterus grows outside the uterus and causes chronic pelvic pain and infertility. However, the exact mechanisms of the pathogenesis of endometriosis-associated infertility are unknown. Epigenetic dysregulation has recently been implicated in infertility. Here, we report a reduction of histone deacetylase 3 (HDAC3) protein amounts in eutopic endometrium of infertile women with endometriosis compared to a control group. To investigate the effect of HDAC3 loss in the uterus, we generated mice with conditional ablation of Hdac3 in progesterone receptor (PG...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
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