Respiratory signs, fever and lymphopenia in calves inoculated with Brazilian HoBi-like pestiviruses

Publication date: Available online 21 July 2018Source: Microbial PathogenesisAuthor(s): J.C. Jardim, B.P. Amaral, M. Martins, P. Sebastian, M.B. Heinemann, A. Cortez, R. Weiblen, E.F. FloresAbstractHobi-like viruses (HobiPeV) comprise a novel, recently classified species of bovine pestiviruses, originally identified in commercial fetal bovine serum of Brazilian origin and, subsequently, isolated from diseased animals in several countries. Although frequently isolated from clinical cases, most HobiPeV isolates failed to reproduce overt disease in cattle upon experimental inoculation. Herein, we describe the outcome of experimental infection of four to six months-old seronegative calves with two Brazilian HobiPeV isolates. Calves inoculated intranasally with isolate SV478/07 developed viremia between days 2 and 9 post-inoculation (pi) and shed virus in nasal secretions up to day 11pi. These animals presented hyperthermia (day 7 to 10–11 pi) and lymphopenia from days 4 to 8pi. Clinically, all four calves developed varied degrees of apathy, anorexia, mild to moderate respiratory signs (nasal secretion, hyperemia), ocular discharge and pasty diarrhea in the days following virus inoculation. In contrast, calves inoculated with isolate SV757/15 presented only hyperthermia (days 3 to 10–11 pi) and lymphopenia (days 4–8 pi), without other apparent clinical signs. In these animals, viremia was detected up to day 9 pi and virus shedding in nasal secretions lasted up to day 12–14...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research