SIRT1 suppresses high glucose and palmitate-induced osteoclast differentiation via deacetylating p66Shc

In conclusion, this study confirms the role of DM in osteoclast differentiation in vitro. SIRT1 suppresses HG- and PA-induced osteoclast differentiation via p66Shc/ROS/NF-κB signaling.
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research