Evidence for the synthesis of an unusual high spin (S = 7/2) [Cu-3Fe-4S] cluster in the radical-SAM enzyme RSAD2 (viperin).

Evidence for the synthesis of an unusual high spin (S = 7/2) [Cu-3Fe-4S] cluster in the radical-SAM enzyme RSAD2 (viperin).
Chem Commun (Camb). 2018 Jul 18;:
Authors: Honarmand Ebrahimi K, Silveira C, Todorovic S
Abstract
We demonstrate the synthesis and spectroscopic characterization of an unusual high spin (S = 7/2) [Cu-3Fe-4S] cluster in a member of the radical-SAM enzymes. This is the first step in using synthetic [Me-3Fe-4S] clusters for obtaining new insight into the mechanism of radical-SAM catalysis.
PMID: 30019036 [PubMed - as supplied by publisher]

Source: Chemical Communications - July 18, 2018 Category: Chemistry Authors: Honarmand Ebrahimi K, Silveira C, Todorovic S Tags: Chem Commun (Camb) Source Type: research