Iodine catalyzed reduction of quinolines under mild reaction conditions.

Iodine catalyzed reduction of quinolines under mild reaction conditions.
Chem Commun (Camb). 2018 Jul 18;:
Authors: Yang CH, Chen X, Li H, Wei W, Yang Z, Chang J
Abstract
A reduction of quinolines to synthetically versatile tetrahydroquinoline molecules with I2 and HBpin is described. In the presence of iodine (20 mol%) as a catalyst, reduction of quinolines and other N-heteroarenes proceeded readily with hydroboranes as the reducing reagents. The broad functional-group tolerance, good yields and mild reaction conditions imply high practical utility.
PMID: 30019712 [PubMed - as supplied by publisher]

Source: Chemical Communications - July 18, 2018 Category: Chemistry Authors: Yang CH, Chen X, Li H, Wei W, Yang Z, Chang J Tags: Chem Commun (Camb) Source Type: research