Working memory deficit in intractable epilepsy with amygdala lesion

This study compared temporal lobe epilepsy (TLE) patients with amygdala lesion (AL) without hippocampal sclerosis (HS) (TLE-AL) and TLE with HS without AL (TLE-HS) (both in the right hemisphere).The TLE-AL group exhibited lower Working Memory Index (WMI) in Wechsler Adult Intelligence Scale, Third Edition (WAIS-III), indicating that the amygdala in the right hemisphere is involved in memory-related function. [18F]fluoro-deoxyglucose positron emission topography (FDG-PET) showed glucose hypometabolism limited in the right uncus for the TLE-AL group.The results suggest the importance of closer attention to cognitive functions in non-dominant hemisphere to prevent impairment after surgery.

Source: Epilepsy and Behavior Case Reports - July 18, 2018 Category: Neurology Source Type: research