UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids.

UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids.
Chem Commun (Camb). 2018 Jul 16;:
Authors: He J, Chen K, Hu ZM, Li K, Song W, Yu LY, Leung CH, Ma DL, Qiao X, Ye M
Abstract
The regiospecific glycosylation of pentacyclic triterpenoids by UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, is highlighted. UGT73F17 exhibited strict substrate specificity toward the carboxyl group at C-30/C-29 of pentacyclic triterpenoids, and showed high promiscuity to sugar donors. UGT73F17 represents the first identified triterpenoid 30/29-O-glycosyltransferase, and could be used as an effective biocatalyst to synthesize glycosyl ester saponins.
PMID: 30010690 [PubMed - as supplied by publisher]

Source: Chemical Communications - July 16, 2018 Category: Chemistry Authors: He J, Chen K, Hu ZM, Li K, Song W, Yu LY, Leung CH, Ma DL, Qiao X, Ye M Tags: Chem Commun (Camb) Source Type: research