Effect of Body Temperature on Cerebral Autoregulation in Acutely Comatose Neurocritically Ill Patients

Objectives:
Impaired cerebral autoregulation following neurologic injury is a predictor of poor clinical outcome. We aimed to assess the relationship between body temperature and cerebral autoregulation in comatose patients.
Design:
Retrospective analysis of prospectively collected data.
Setting:
Neurocritical care unit of the Johns Hopkins Hospital.
Patients:
Eighty-five acutely comatose patients (Glasgow Coma Scale score of ≤ 8) admitted between 2013 and 2017.
Interventions:
None.
Measurement and Main Results:
Cerebral autoregulation was monitored using multimodal monitoring with near-infrared spectroscopy–derived cerebral oximetry index. Cerebral oximetry index was calculated as a Pearson correlation coefficient between low-frequency changes in regional cerebral oxygenation saturation and mean arterial pressure. Patients were initially analyzed together, then stratified by temperature pattern over the monitoring period: no change (

Source: Critical Care Medicine - July 14, 2018 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research