Surgical Patients With Solid Cancers Fare No Worse in ICU Surgical Patients With Solid Cancers Fare No Worse in ICU

Surgical patients with solid cancer fare just as well in intensive care units as those without cancer, according to Scottish researchers.Reuters Health Information
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Hematology-Oncology News Source Type: news

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Publication date: Available online 20 October 2018Source: Journal of Molecular Graphics and ModellingAuthor(s): Süleyman Selim Çınaroğlu, Emel TimuçinAbstractReplication Protein A (RPA) mediates DNA Damage Response (DDR) pathways through protein-protein interactions (PPIs). Targeting the PPIs formed between RPA and other DNA Damage Response (DDR) mediators has become an intriguing area of research for cancer drug discovery. A number of studies applied different methods ranging from high throughput screening approaches to fragment-based drug design tools to discover RPA inhibitors. Although these method...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
Publication date: Available online 21 October 2018Source: Journal of Theoretical BiologyAuthor(s): Claude Gérard, Didier Gonze, Albert GoldbeterAbstractA network of cyclin-dependent kinases (Cdks) regulated by multiple negative and positive feedback loops controls progression in the mammalian cell cycle. We previously proposed a detailed computational model for this network, which consists of four coupled Cdk modules. Both this detailed model and a reduced, skeleton version show that the Cdk network is capable of temporal self-organization in the form of sustained Cdk oscillations, which correspond to the orderly pr...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Publication date: Available online 21 October 2018Source: American Journal of Preventive MedicineAuthor(s): Soham Gupta, Alexander P. Cole, Maya Marchese, Ye Wang, Jacqueline M. Speed, Sean A. Fletcher, Junaid Nabi, Sebastian Berg, Stuart R. Lipsitz, Toni K. Choueiri, Steven L. Chang, Adam S. Kibel, Annemarie Uhlig, Quoc-Dien TrinhIntroductionWith improvements in early detection and treatment, a growing proportion of the population now lives with a personal history of a cancer. Although many cancer survivors are in excellent health, the underlying risk factors and side effects of cancer treatment increase the risk of medic...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Whole-breast radiation therapy can significantly lower the risk of recurrent...Read more on AuntMinnie.comRelated Reading: Can dedicated breast PET identify suspicious lesions? Women still need breast imaging after mastectomy Is radiation therapy warranted for DCIS postlumpectomy? Microbubbles improve breast cancer radiation therapy ASTRO: Short radiation course safe for breast cancer
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Authors: Buchanan T, Mutch D Abstract INTRODUCTION: Although a relatively uncommon disease, the treatment of vulvar cancer has changed considerably over the years and has been under considerable focus due to its past overtreatment and apparent increase in incidence. The purpose of this review is to describe the recommended management of the most commonly encountered vulvar carcinomas based on the most recent available literature. Areas covered: The clinical environment of squamous cell vulvar cancers are illustrated in order to describe the potential pitfalls and limitations of treatment. Then, by examining publish...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
A larger, weekly dose of radiation therapy has side effects that are comparable...Read more on AuntMinnie.comRelated Reading: Can dedicated breast PET identify suspicious lesions? Women still need breast imaging after mastectomy Is radiation therapy warranted for DCIS postlumpectomy? Microbubbles improve breast cancer radiation therapy ASTRO: Short radiation course safe for breast cancer
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
s P Abstract Besides providing the majority of ATP production in cells, mitochondria are also involved in many other cellular functions and are central for cellular stress signaling. Mitochondrial dysfunction induces not only inherited mitochondrial disorders but also contributes to neurodegenerative diseases, cancer, diabetes, and metabolic syndrome. The HSP60/HSP10 molecular chaperone complex facilitates folding of mitochondrial proteins and is thus an important factor for many mitochondrial functions. To model different degrees of oxidative stress and mitochondrial dysfunction we here describe a HEK293 derived ...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Authors: Sang MM, Liu FL, Wang Y, Luo RJ, Huan XX, Han LF, Zhang ZT, Feng F, Qu W, Liu W, Zheng F Abstract Gambogic acid (GA) is a naturally derived potent anticancer agent with extremely poor biocompatibility. In the present study, a novel of redox/pH dual-responsive multifunctional magnetic complex micelle (sPEG/HA/CSO-SS-Hex/Fe3O4/GA), which consisted of a reducible hexadecanol-modified chitosan oligosaccharide polymer micelle (CSO-SS-Hex) coated with hyaluronic acid (HA) and DCA grafted sheddable PEG-PLL (sPEG) copolymers and loaded with gambogic acid (GA) and Fe3O4 nanoparticles were developed for parenteral d...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Authors: Lager TW, Roetman JJ, Kunkel J, Thacker M, Sheets JN, Egland KA, Miles CM, Larson MK, Gubbels JAA Abstract Platelets play a central role in primary hemostasis affecting tumor survival and metastases. Tumors induce platelets to aggregate and bind to the cancer cells, resulting in protection from immune surveillance and often leading to thrombocytosis. In ovarian cancer (OvCa), one-third of patients present with thrombocytosis, a diagnosis that correlates with shorter survival. SUSD2 (SUShi Domain containing 2), a type I transmembrane protein, shown to inhibit metastatic processes in high-grade serous ovaria...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
(MedPage Today) -- Atezolizumab-chemo combo extends PFS, OS in metastatic disease
Source: MedPage Today OB/GYN - Category: OBGYN Source Type: news
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