Patients With Down Syndrome May Have Keratoconus-Like Corneas Patients With Down Syndrome May Have Keratoconus-Like Corneas

Over 70% of people with Down syndrome (DS) - many more than previously thought - may have corneas similar in morphology to the corneas of people with keratoconus, a new study reports.Reuters Health Information
Source: Medscape Radiology Headlines - Category: Radiology Tags: Ophthalmology News Source Type: news

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CONCLUSIONS: Clinical application of CMA as a first-tier test improves diagnostic yields and the quality of clinical management in patients with DD/ID, ASD, and MCA. PMID: 30623622 [PubMed - in process]
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research
Down syndrome (DS) is the most common form of viable chromosomal abnormality. DS is associated with recurrent infections, auto-immunity and malignancies in children. Little is known about immunity and infectio...
Source: Orphanet Journal of Rare Diseases - Category: Internal Medicine Authors: Tags: Letter to the Editor Source Type: research
Abstract Children undergoing cardiac surgery often receive acetaminophen (paracetamol) as part of their postoperative pain treatment. To date, there is no information on the pharmacokinetics (PK) of acetaminophen in this special population, even though differences, as a result of altered hemodynamics and/or use of cardiopulmonary bypass, may be anticipated. Therefore, the aim of this study was to investigate the PK of intravenous acetaminophen in children after cardiac surgery with cardiopulmonary bypass. In the study, both children with and without Down syndrome were included. A population PK analysis, using NONM...
Source: The Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: J Clin Pharmacol Source Type: research
Conclusion: Both the prevalence of biopsy-proven CD (10.6%) and seroprevalence (15.6%) were higher than those we previously reported in the normal population (1.4% and 2.7%). The female-to-male ratio (1.9/1) of CD patients was the same in normal and at-risk populations in SA. Meta-analysis for prevalence of CD in DM, SS, and DS separately in SA is recommended. PMID: 30617375 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
This article describes how screening for fetal trisomy  21 has evolved from advanced maternal age, with a detection rate of 30% at a false positive rate (FPR) of 5%, to second trimester serum biochemistry, with a detection rate of 60–75% at an FPR of 5%, and then to the first trimester combination of fetal nuchal translucency and serum biochemistry, with a detection rate of 90% at an FPR of 5%. The introduction of cell‐free DNA analysis of maternal blood is outlined. This method has improved detection rate to 99% with a reduction in FPR to 0.1%. As this test is currently expensive, it may be difficult to off...
Source: The Obstetrician and Gynaecologist - Category: OBGYN Authors: Tags: Reviews Source Type: research
Title: Experts Outline Down Syndrome's Developmental MilestonesCategory: Health NewsCreated: 1/7/2019 12:00:00 AMLast Editorial Review: 1/8/2019 12:00:00 AM
Source: MedicineNet Kids Health General - Category: Pediatrics Source Type: news
CONCLUSIONS: There are a few high quality studies addressing dual-task effects on activities performed by children with neuromotor dysfunctions. These children show greater susceptibility to dual-task costs than typical ones. There is a lack of studies addressing children with CP and Down syndrome, which are highly prevalent and commonly seen in clinical settings. Thus, dual-task effects in children with neuromotor dysfunctions remain a wide research field, with need for further studies to fill in the existing gaps. PMID: 30621370 [PubMed - as supplied by publisher]
Source: European Journal of Physical and Rehabilitation Medicine - Category: Rehabilitation Authors: Tags: Eur J Phys Rehabil Med Source Type: research
MONDAY, Jan. 7, 2019 -- Parents of kids with Down syndrome often worry whether their children can develop life skills, but new research suggests that the picture is far from bleak. " More and more parents are opting for prenatal testing during their...
Source: - Daily MedNews - Category: General Medicine Source Type: news
American Journal on Intellectual and Developmental Disabilities,Volume 124, Issue 1, Page 4-10, January 2019.
Source: American Journal on Intellectual and Developmental Disabilities - Category: Disability Authors: Source Type: research
Source: Journal of Maternal-Fetal and Neonatal Medicine - Category: Perinatology & Neonatology Authors: Source Type: research
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