Selenium-dependent gene expression in Methanococcus maripaludis: Involvement of the transcriptional regulator HrsM

ConclusionsHrsM exerts a key role in regulating expression of selenoprotein genes and their Cys-encoding isogenes in M. maripaludis in a selenium-dependent fashion. However, this activity is not achieved via autoregulation but probably by a mechanism, which modulates the DNA-binding of HrsM.General significanceAlthough LTTRs are abundant in Bacteria, HrsM represents only the second characterized member of this group in Archaea.

Source: Biochimica et Biophysica Acta (BBA) General Subjects - July 11, 2018 Category: Biochemistry Source Type: research