Advances in absolute protein quantification and quantitative protein mapping using ICP-MS

Publication date: July 2018Source: TrAC Trends in Analytical Chemistry, Volume 104Author(s): Laura Cid-Barrio, Francisco Calderón-Celis, Patricia Abásolo-Linares, M. Luisa Fernández-Sánchez, José Manuel Costa-Fernández, Jorge Ruiz Encinar, Alfredo Sanz-MedelAbstractProtein and peptide detection with inductively coupled plasma mass spectrometry (ICP-MS) can provide their direct and reliable absolute quantification without the need for specific standards, which greatly complements molecular mass spectrometry features in proteomics. We discuss recent research to shed new light on this particular surge in the analytical applicability of ICP-MS and identify possible niches that could attract future analytical activity within this emerging field.

Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research