New norclerodane diterpenoids from Dioscorea bulbifera

Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Guo-Kai Wang, Juan Zheng, Yun-peng Sun, Wen-fang Jin, Hui-wen Liu, Yang Yu, Zhong-yu Zhou, Jin-song LiuAbstractThree new norclerodane diterpenoids, diosbulbin E acetate (1), diosbulbin R (2), and diosbulbin S (3), and seven known compounds (4-10) were isolated from an ethanol extract of Dioscorea bulbifera tubers. The structure of compounds 1–10 was determined through extensive NMR and mass spectroscopic analyses. The new compounds were investigated to determine their cytotoxic activity against the SMMC-7721 cancer cell line.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research