GSE112686 Effect of hyperfractionated irradiation (HFRT) of prostate primary basal cells (PrEPs) on the transcriptome

Contributors : Fabian Guggenberger ; Harmen J van de Werken ; Holger H Erb ; Giuseppe Cappellano ; Kristina Trattnig ; Florian Handle ; Sarah Peer ; Georg Sch äfer ; Guido Jenster ; Zoran Culig ; Ira-Ida Skvortsova ; Frédéric R SanterSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe irradiated PrEPs derived from four patients undergoing radical prostatectomy according to a HFRT protocol (20 single treatments). Transcriptome was analysed by NextGen sequencing. Gene expression profiling revealed a dysregulation of 3468 genes at mRNA level (1470 upregulated and 1998 downregulated). We could characterize cells surviving the lethal effects of radiation by two gene expression signatures showing that these cells have low expression of genes related to DNA damage response and Interferon signaling pathways. These findings could be exploited to develop new drugs for radiotherapy improvement.

Source: GEO: Gene Expression Omnibus - July 9, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research