Rapid paper based colorimetric detection of glucose using a hollow microneedle device

Publication date: 25 August 2018Source: International Journal of Pharmaceutics, Volume 547, Issues 1–2Author(s): Dean Nicholas, Keiran A. Logan, Yingjie Sheng, Jinhui Gao, Sian Farrell, Dorian Dixon, Bridgeen Callan, Anthony P. McHale, John F. CallanAbstractThe monitoring of blood glucose is a key aspect of diabetes care in limiting the negative effects of hyperglycaemia to both the microvasculature and macrovasculature. Self-monitoring of blood glucose (SMBG) gives an indication of blood glucose at a specific point in time and is recommended to be carried out four times daily. However, due to the inconvenience and associated pain of blood withdrawal, SMBG is often carried out less frequently than recommended or not at all. Extraction and subsequent determination of glucose in interstitial fluid (ISF) using microneedles (MNs) is an emerging area of research due to their minimally invasive nature and lack of associated pain. In this manuscript, a novel method for the fabrication of a hollow microneedle device is reported. The microneedle produced had a sharp bevelled edge and was 400 µm in length. Additionally, a paper backplate embedded with a colorimetric system for the rapid visual determination of glucose in simulated ISF was developed and paired with the hollow MN. This device rapidly extracted simulated ISF within five seconds and its ability to produce a glucose concentration dependent colour change within 30 s was demonstrated. Using this approach, it w...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 8 December 2018Source: NeuroscienceAuthor(s): Juliana Maia Teixeira, Gilson Gonçalves dos Santos, Amanda Ferreira Neves, Maria Carolina Pedro Athie, Ivan José Magayewski Bonet, Catarine Massucato Nishijima, Felipe Hertzing Farias, Jozi Godoi Figueiredo, Victor Hernandez-Olmos, Samer Alshaibani, Cláudia Herrera Tambeli, Christa E. Müller, Carlos Amílcar ParadaAbstractPeripheral diabetic neuropathy (PDN) manifests in 50-60% of type I and II diabetic patients and is the major cause of limb amputation. Adequate therapy for PDN is a current challenge. There are...
Source: Neuroscience - Category: Neuroscience Source Type: research
CONCLUSION: This study provides further insight into the patients' wound pain experiences during NPWT and its effect on daily activities. Increased awareness about NPWT-associated pain and pain control measures as well as qualitative and controlled quantitative studies are needed. Inservice training and educational meetings should be conducted at surgical clinics to expand surgical nurse and physician knowledge and awareness of how to efficiently manage pain during NPWT treatment and related procedures. PMID: 30516480 [PubMed - in process]
Source: Ostomy Wound Management - Category: Surgery Tags: Ostomy Wound Manage Source Type: research
Authors: Wildes TM, Anderson KC Abstract Mrs. A. is a 73-year-old woman who has developed increasing fatigue and lower back pain over the past year. The pain limits her exercise tolerance such that she can now walk only 1 block. She is a retired schoolteacher who does volunteer efforts in her community but has limited her activities due to fatigue. Karnofsky performance status is 70%. She has a history of chronic hypertension treated with a diuretic, adult-onset diabetes mellitus treated with metformin, and hypothyroidism treated with levothyroxine. Initial evaluation reveals anemia, renal dysfunction, an elevated ...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
Authors: Facon T, Anderson K Abstract Mrs. A. is a 73-year-old woman who has developed increasing fatigue and lower back pain over the past year. The pain limits her exercise tolerance such that she can now walk only 1 block. She is a retired schoolteacher who does volunteer efforts in her community but has limited her activities due to fatigue. Karnofsky performance status is 70%. She has a history of chronic hypertension treated with a diuretic, adult-onset diabetes mellitus treated with metformin, and hypothyroidism treated with levothyroxine. Initial evaluation reveals anemia, renal dysfunction, an elevated tot...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
People who work in manual labor have higher rates of injury and overdose Our country’s ongoing opioid crisis has many faces, from teenagers on Cape Cod to middle-aged parents in West Virginia. A recent report from the Massachusetts Department of Public Health provides another demographic affected by opioids: people who work in the trade industries, namely construction. The report broke down overdose deaths by industry, and construction workers were involved in almost a quarter of overdose deaths recorded in the state over five years. Farming, forestry, and hunting, along with fishing, are the next most dangerous indu...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Addiction Source Type: blogs
DiscussionThis systematic review and meta-analysis will summarise the evidence on pain threshold profiles and pain modulation mechanisms in people with diabetes without and with neuropathies (both painful and non-painful). This will provide more insight in the clinical presentation and progression of diabetic neuropathies.Systematic review registrationPROSPEROCRD42018088173
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
Chronic pain after lower extremity amputation surgery has been reported in up to 80% of patients. Amputations are among the most debilitating chronic complication of diabetes with a variety of consequences including depression, inability to perform daily activities, and change in quality of life.
Source: Pain Management Nursing - Category: Nursing Authors: Tags: Original Article Source Type: research
We report a 66-year-old male who developed diabetic ketoacidosis (DKA) and necrosis of the small intestine due to non-occlusive mesenteric ischemia (NOMI), 3  months after starting quetiapine treatment. He was transferred to our hospital and diagnosed as diabetic for the first time, associated with DKA. Despite improvement in DKA, abdominal pain worsened gradually 10 h after hospitalization. Computed tomography (CT) revealed bowel emphysema, and gas ou t of the gut wall, in the mesenteric veins and the intrahepatic portal vein, suggesting intestinal necrosis. He survived because of resection of necrotic small-int...
Source: Diabetology International - Category: Endocrinology Source Type: research
This study compared utilization patterns of high-cost services and medications for patients receiving care from Accountable Care Organization (ACO)-participating physicians and those receiving care from non-ACO physicians during the initial phases of ACO development in a commercially insured environment. Patients ≥18 years (≥40 years for chronic obstructive pulmonary disease [COPD]) with prevalent rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, type 2 diabetes, COPD, or chronic low back pain between January 1, 2012, and August 31, 2014 were identified in the HealthCore Integrated Research Databa...
Source: Pain Physician - Category: Anesthesiology Authors: Tags: Popul Health Manag Source Type: research
  I previously shared Tammy’s Wheat Belly success story that illustrates just how far you can take back health and reverse numerous chronic health conditions. Besides losing over 70 pounds in weight, she also: Reversed type 2 diabetes, reducing HbA1c from the diabetic range of 8.4% to 4.9%—an ideal level. Reversed hypertension Reversed gastroesophageal reflux Reversed irritable bowel syndrome Reversed rheumatoid arthritis She has also been able to discontinue a list of toxic medications, including metformin, Prilosec, and Remicade. And, as you can readily see, turned the clock back 20 years in appearance...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates autoimmune blood sugar diabetes gastroesphageal gerd Gliadin gluten gluten-free grain-free grains high blood pressure hypertension Inflammation irritable bowel its Weight Loss wheat belly Source Type: blogs
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