Noninvasive Imaging Could Help Diagnose Rejection in Lung Recipients Noninvasive Imaging Could Help Diagnose Rejection in Lung Recipients
Probe-based confocal laser endomicroscopy (pCLE) could help identify acute cellular rejection (ACR) in lung allografts, a preliminary study suggests.Reuters Health Information
CONCLUSION: The LT-QOL is a new multidimensional instrument that characterizes and quantifies health-related quality of life in lung transplant recipients. PMID: 30303408 [PubMed - as supplied by publisher]
Abstract PURPOSE OF REVIEW: Bioengineering the lung based on its natural extracellular matrix (ECM) offers novel opportunities to overcome the shortage of donors, to reduce chronic allograft rejections, and to improve the median survival rate of transplanted patients. During the last decade, lung tissue engineering has advanced rapidly to combine scaffolds, cells, and biologically active molecules into functional tissues to restore or improve the lung's main function, gas exchange. This review will inspect the current progress in lung bioengineering using decellularized and recellularized lung scaffolds and highli...
Conclusion: This case highlights the clinical significance of AMR in lung allografts, as well as the need to investigate both HLA and non-HLA antibody sources in pulmonary transplant rejection refractory to treatment. PMID: 30275791 [PubMed]
Long-term survival after lung transplantation (LTx) is hampered by chronic lung allograft dysfunction (CLAD). Our study aimed to evaluate prevalence and prognostic importance of obstructive and restrictive CLAD phenotypes with or without identifiable underlying cause to validate the recently proposed classification system for CLAD.
Authors: Kawai H, Tsujigiwa H, Siar CH, Nakano K, Takabatake K, Fujii M, Hamada M, Tamamura R, Nagatsuka H Abstract Background: The tumor microenvironment and its stromal cells play an important role in cancer development and metastasis. Bone marrow-derived cells (BMDCs), a rich source of hematopoietic and mesenchymal stem cells, putatively contribute to this tumoral stroma. However their characteristics and roles within the tumor microenvironment are unclear. In the present study, BMDCs in the tumor microenvironment were traced using the green fluorescent protein (GFP) bone marrow transplantation model. Methods: C...
AbstractPurpose of ReviewSynthesize recent developments in the understanding of chronic lung allograft dysfunction (CLAD) epidemiology, pathophysiology, outcomes, and treatments with a focus on the classification of CLAD into restrictive allograft syndrome (RAS) and from bronchiolitis obliterans syndrome (BOS).Recent FindingsChronic lung allograft dysfunction (CLAD) remains the leading cause of long-term morbidity and mortality in lung transplant recipients. Despite the lack of progress on improving outcomes, significant progress has been made in better characterizing the disease ’s clinical and pathologic diversity....
In this study, 22 patients were transplanted with preexisting DSA, and 43 patients developed ndDSA posttransplant. Pretransplant (P
Pediatric heart transplant waitlist mortality remains significant but allograft offer refusals are common and allografts continue to be discarded.
Lung transplantation (LTx) recipients have 1-, 5-, and 10-year unadjusted survival rates of 80%, 54%, and 32%, respectively.1 Chronic lung allograft dysfunction (CLAD) causes most deaths after the first post-transplant year,1 –3 and most CLAD has an obstructive phenotype known as bronchiolitis obliterans syndrome (BOS).4 Obliterative bronchiolitis (OB), the histologic hallmark of BOS, consists of a fibrotic luminal obliteration of the respiratory and terminal bronchioles.5 The patchy nature of OB reduces the diagnostic sensitivity of transbronchial lung biopsies.
Blood type O lung allografts may be allocated to either blood type identical (type O) or compatible (Non-O) candidates. We tested the hypothesis that the current organ allocation schema in the U.S. - based on the LAS - prejudices against the allocation of allografts to type O candidates, given that the pool of potential donors is smaller.