The Respiratory Infections Team a novel paradigm in the management of community-acquired pneumonia

This shared learning outlines how a Respiratory Infections Team was developed at Royal Derby Hospital, comprising 3 specialist nurses supported by a respiratory consultant and antimicrobial pharmacist. Its aims were to review patients admitted to hospital and to improve concordance with NICE pneumonia guidelines.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Conditions:   Severe Pneumonia;   Hypoxemia Intervention:   Device: Pulse Oximetry Sponsors:   Aga Khan University;   Bill and Melinda Gates Foundation Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Yonglin Zhou, Tingting Wang, Yan Guo, Shui Liu, Jianfeng Wang, Yingbo Shen, Shusheng Tang, Yang Wang, Xuming Deng
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
The European Centre for Disease Prevention and Control is warning that tourists in Gran Canaria have been infected with the Klebsiella pneumoniae bacteria, which can cause pneumonia.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Lydia Hopp, Henry Loeffler-Wirth, Lilit Nersisyan, Arsen Arakelyan, Hans Binder
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The use of broad-spectrum antibiotics in empirical antimicrobial therapy is a lifesaving strategy for patients in intensive care. At the same time, antibiotics dramatically increase the risk for nosocomial infections, such as hospital‑acquired pneumonia caused by Pseudomonas aeruginosa, and other antibiotic-resistant bacteria. In this issue of the JCI, Robak and colleagues identified a mechanism by which depletion of resident gut and lung microbiota by antibiotic treatment results in secondary IgA deficiency and impaired anti–P. aeruginosa host defense. Impaired defenses could be improved by substitution of polyclo...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Broad-spectrum antibiotics are widely used with patients in intensive care units (ICUs), many of whom develop hospital-acquired infections with Pseudomonas aeruginosa. Although preceding antimicrobial therapy is known as a major risk factor for P. aeruginosa–induced pneumonia, the underlying mechanisms remain incompletely understood. Here we demonstrate that depletion of the resident microbiota by broad-spectrum antibiotic treatment inhibited TLR-dependent production of a proliferation-inducing ligand (APRIL), resulting in a secondary IgA deficiency in the lung in mice and human ICU patients. Microbiota-dependent loc...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
ore V. Giofrè Pyrimidine-1,3-oxazolidin-2-arylimino hybrids have been synthesized as a new class of antibacterial agents. The synthetic approach exploits a Cu(II)-catalyzed intramolecular halkoxyhalogenation of alkynyl ureas, followed by a Suzuki coupling reaction with 2,4-dimethoxypyrimidin-5-boronic acid. Biological screenings revealed that most of the compounds showed moderate to good activity against two Gram-positive (B. subtilis, S. aureus) and three Gram-negative (P. aeruginosa, S. typhi, K. pneumonia) pathogenic strains. A molecular docking study, performed in the crystal structure of 50S ribosomal unit ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
The yeast-like fungi Pneumocystis, resides in lung alveoli and can cause a lethal infection known as Pneumocystis pneumonia (PCP) in hosts with impaired immune systems. Current therapies for PCP, such as trimetho...
Source: BMC Systems Biology - Category: Molecular Biology Authors: Tags: Research article Source Type: research
Conclusion: This study reveals that the prevalence of MDR Gram-negative pathogens is perceived to be on the rise. Prescription patterns indicate high levels of variability. Hence, antibiotic stewardship is essential to standardize antibiotic prescriptions not only for efficacy but also to reduce the burden of multiple drug resistance.
Source: Indian Journal of Critical Care Medicine - Category: Intensive Care Authors: Source Type: research
Conclusions: C. indologenes infections are increasing because of higher use of carbapenems and colistin, to which it is intrinsically resistant.
Source: Indian Journal of Critical Care Medicine - Category: Intensive Care Authors: Source Type: research
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