Inhibition Mechanism of Acellular Dermal Matrix on Capsule Formation in Expander –Implant Breast Reconstruction After Postmastectomy Radiotherapy

ConclusionsUse of ADM reduced myofibroblasts, vascularity, fibroblasts, and EndoMT in capsule tissues. Moreover, ADM use decreased macrophages, a key regulator of tissue fibrosis, as well asTGF-β1 andPDGF-B expression. We hope that these results provide basic concepts important for prevention of capsular contracture.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research