Nematicidal compounds of Peperomia japonica

Publication date: October 2018 Source:Phytochemistry Letters, Volume 27 Author(s): Kazumi Nagashima, Yoshi Yamano, Sachiko Sugimoto, Kenji Ishiwata, Hirotaka Kanuka, Hideaki Otsuka, Katsuyoshi Matsunami On antiparasitic screening, we found that extracts of Peperomia japonica have nematicidal activity. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of one new polyketide (1), two new seco-lignans (2, 3), and two known polyketides (4, 5). The structures of these compounds were established by extensive one- and two-dimensional nuclear magnetic resonance spectroscopy and high-resolution electrospray ionization mass spectrometry analyses. Compounds 1 and 4 show strong lethal activity toward Caenorhabditis elegans and Heligmosomoides polygyrus. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

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