PCOS linked to maternal obesity and smoking

A Swedish study, published inBJOG: An International Journal of Obstetrics& Gynaecology, reports that those diagnosed with PCOS are more likely to have obese mothers or mothers that smoked during pregnancy.Healio
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Abstract BACKGROUND: Letrozole is widely employed as ovulation induction agent in women with PCOS, but its use in mild stimulation (MS) protocols for IVF is limited. Aim of the present study was to evaluate the feasibility of a MS protocol with letrozole plus hMG in non-obese PCOS women undergoing IVF after a metformin pre-treatment. METHODS: We retrospectively evaluated the data of 125 non-obese PCOS undergoing MS with letrozole plus hMG, 150 IU as starting dose, (group 1, N = 80) compared to those undergoing a conventional IVF stimulation protocols (CS) (group 2, N = 45) pri...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
One of the commonest questions which patients ask me is - What ispolycystic ovariandisease (or PCO, also known as PCOD and PCOS? ) And what are its risks ?This has now become a very common diagnosis, and is made by gynecologists, dietitians, skin specialists and GPs as well. The diagnosis is made typically for young girls, who are worried because they irregular periods; are a little bit overweight; or have acne or some oily skin. Doctors order a panel of expensive blood tests ( which measure hormones levels such as FSH, LH, DHEA, testosterone and AMH), and these often turn out to be abnormal in these girls.The problem...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
AbstractPurposeThe aim of this study is to examine the impact of female body mass index (BMI) on IVF cycle outcomes.MethodsThis is a retrospective cohort study including 51,198 women who initiated their first autologous IVF cycle in 13 fertility centers in the USA between 2009 and 2015. The effect of underweight, overweight, and obese BMI on four different IVF cycle outcomes (cycle cancellation, oocyte and embryo counts, and ongoing clinical pregnancy [OCP]) was evaluated in logistic or Poisson regression analyses with confounders adjusted.ResultsWomen with an overweight or obese BMI experienced worse outcomes than those w...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
ConclusionCompared to non-PCOS patients, PCOS patients had greater postoperative ΔBMI and %EWL at 1 year. The majority of patients becoming pregnant after VSG were previously nulliparous. This study shows that VSG is effective for weight loss in PCOS patients with obesity and may positively augment effect fertility rates.
Source: Obesity Surgery - Category: Surgery Source Type: research
Authors: Artini PG, Obino MER, Sergiampietri C, Pinelli S, Papini F, Casarosa E, Cela V Abstract INTRODUCTION: Polycystic ovary syndrome (PCOS) is a common cause of female infertility affecting multiple aspects of a women's health. Areas covered: The aim of this review is to summarize the existing evidence on the treatment of PCOS patients and to examine the actual available therapies to overcome the problem of infertility and improve the outcome of pregnancy. We analyse different treatment strategies such as lifestyle modification, bariatric surgery, insulin sensitizing agents, inositol, clomiphene citrate (CC), a...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
Abstract Context: Women with PCOS are at increased risk for pregnancy complications possibly related to pre-existing obesity and potentially to excessive gestational weight gain (GWG). Objectives: To assess the contributions of pre-existing diagnosis and preconception weight on GWG and perinatal outcomes. Research Design and Methods: Prospective cohort study of singleton pregnancies in PCOS(N =164) and ovulatory controls(N = 176) conceiving from infertility treatment. Main Outcome measures: GWG, birthweight, pregnancy complications. Results: From pre-conception baseline, normal-weight PCOS women gai...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
Women who are overweight or smoke during pregnancy are more likely to have daughters who develop polycystic ovary syndrome, a nationwide study has found.
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
CONCLUSION: First line management of infertility once a diagnosis of PCOS is made should include weight loss and exercise with goals to below class 2 obesity (BMI
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Abstract Polycystic ovary syndrome (PCOS) is common in premenopausal women. The majority of women with PCOS have insulin resistance and the risk of type 2 diabetes mellitus (T2D) is higher in women with PCOS compared to controls. In non-pregnant women with PCOS, glycemic status may be assessed by oral glucose tolerance test (OGTT), fasting plasma glucose (FPG), or HbA1c. OGTT has been reckoned gold standard test for diagnosing T2D, but OGTT is rarely used for diagnostic purpose in other non-pregnant individuals at risk of T2D, apart from PCOS. OGTT has questionable reproducibility, and the high sensitivity of the ...
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research
AbstractPurpose of ReviewCardiovascular disease (CVD) is the leading cause of death among women in the USA, accounting for one of every three deaths. Physical activity (PA) has been shown to have numerous beneficial effects for CVD risk reduction in women. Nonetheless, much of the previous research on the impact of PA on CVD risk factors has been measured using self-report questionnaires. The purpose of this review was to summarize the main findings for the association between objectively measured PA and PA interventions on traditional and nontraditional CVD risk factors from randomized controlled trials (RCT), cohort, and...
Source: Current Cardiovascular Risk Reports - Category: Cardiology Source Type: research
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