PCOS linked to maternal obesity and smoking

A Swedish study, published inBJOG: An International Journal of Obstetrics& Gynaecology, reports that those diagnosed with PCOS are more likely to have obese mothers or mothers that smoked during pregnancy.Healio
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Women who are overweight or smoke during pregnancy are more likely to have daughters who develop polycystic ovary syndrome, a nationwide study has found.
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
CONCLUSION: First line management of infertility once a diagnosis of PCOS is made should include weight loss and exercise with goals to below class 2 obesity (BMI
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Abstract Polycystic ovary syndrome (PCOS) is common in premenopausal women. The majority of women with PCOS have insulin resistance and the risk of type 2 diabetes mellitus (T2D) is higher in women with PCOS compared to controls. In non-pregnant women with PCOS, glycemic status may be assessed by oral glucose tolerance test (OGTT), fasting plasma glucose (FPG), or HbA1c. OGTT has been reckoned gold standard test for diagnosing T2D, but OGTT is rarely used for diagnostic purpose in other non-pregnant individuals at risk of T2D, apart from PCOS. OGTT has questionable reproducibility, and the high sensitivity of the ...
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research
AbstractPurpose of ReviewCardiovascular disease (CVD) is the leading cause of death among women in the USA, accounting for one of every three deaths. Physical activity (PA) has been shown to have numerous beneficial effects for CVD risk reduction in women. Nonetheless, much of the previous research on the impact of PA on CVD risk factors has been measured using self-report questionnaires. The purpose of this review was to summarize the main findings for the association between objectively measured PA and PA interventions on traditional and nontraditional CVD risk factors from randomized controlled trials (RCT), cohort, and...
Source: Current Cardiovascular Risk Reports - Category: Cardiology Source Type: research
CONCLUSIONS: Maternal smoking and increased BMI appear to increase the risk of PCOS in offspring. The association between SGA and the development of PCOS appears to be mediated by maternal factors. TWEETABLE ABSTRACT: Smoking during pregnancy and high maternal BMI are associated with PCOS diagnosis in the offspring. PMID: 29896923 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
AbstractObjectiveTo investigate the effects of body mass index (BMI) on the outcomes of in vitro fertilization (IVF) in Chinese patients with polycystic ovary syndrome (PCOS).MethodsIn the retrospective cohort study, a total of 1074 patients with PCOS undergoing IVF between April 2010 and May 2017 in two reproductive medicine centers, respectively in eastern China (Women ’s Hospital, School of Medicine, Zhejiang University, Zhejiang Province) and in southern China (Maternal and Child Health Care Hospital of Liuzhou, Guangxi Province), were included. The patients were divided into four groups according to the recommen...
Source: Journal of Zhejiang University. Science. B. - Category: Universities & Medical Training Source Type: research
CONCLUSIONS: There is a high probability that metformin use is associated with a reduced HDP incidence when compared to other treatments and placebo. The small number of studies included in the analysis, the low quality of evidence and the clinical heterogeneity preclude the generalization of these results to broader populations. Given the clinical importance of this topic and the magnitude of effect observed in this meta-analysis, further prospective trials are urgently needed. This article is protected by copyright. All rights reserved. PMID: 29749110 [PubMed - as supplied by publisher]
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
CONCLUSIONS: Preconception intervention with low-dose liraglutide added to metformin is superior to metformin alone in increasing PRs per ET and cumulative PRs in infertile obese women with PCOS, despite comparable weight reduction in both groups. A potential direct crosstalk between GLP-1 and reproductive system needs further exploration. PMID: 29703793 [PubMed - as supplied by publisher]
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research
Overweight/obese women with polycystic ovary syndrome (PCOS) are at increased risk of subfertility and complications of pregnancy, compared with normal-weight women. To implement controlled ovarian hyperstimul...
Source: Reproductive Biology and Endocrinology - Category: Endocrinology Authors: Tags: Research Source Type: research
Abstract BACKGROUND: Overweight/obese women with polycystic ovary syndrome (PCOS) are at increased risk of subfertility and complications of pregnancy, compared with normal-weight women. To implement controlled ovarian hyperstimulation (COH), the improved efficacy of the gonadotrophin-releasing hormone antagonist (GnRH-ant) protocol has been demonstrated, as well as frozen embryo transfer (FET). OBJECTIVE: This retrospective study evaluated the pregnancy outcomes after combined GnRH-ant protocol and FET in overweight/obese women with PCOS, with reference to that of normal-weight women with PCOS. METHODS:...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
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