PCOS linked to maternal obesity and smoking

A Swedish study, published inBJOG: An International Journal of Obstetrics& Gynaecology, reports that those diagnosed with PCOS are more likely to have obese mothers or mothers that smoked during pregnancy.Healio
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Authors: Schneider D, Gonzalez JR, Yamamoto M, Yang J, Lo JC Abstract Purpose: To examine the association of polycystic ovary syndrome (PCOS) and pregnancy-induced hypertension (PIH) within a large population of pregnant women in an integrated healthcare system. Methods: This retrospective study utilized a source cohort of 1023 women with PCOS and 1023 women without PCOS who had a delivered pregnancy within Kaiser Permanente Northern California. Preexisting hypertension was defined by hypertension diagnosis, treatment, or elevated blood pressure prior to 20 weeks of gestation. The development of PIH, including ...
Source: Journal of Pregnancy - Category: OBGYN Tags: J Pregnancy Source Type: research
CONCLUSION: In addition to pharmacological interventions, long-term standardized individualized management of PCOS patients is needed to achieve fertility and reduce the risk of metabolic related diseases. PMID: 30706800 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with poor reproductive outcomes, including infertility and pregnancy complications, and poor metabolic outcomes, including insulin resistance, type 2 diabetes, and the metabolic syndrome. Prevalence estimates for PCOS range from 7% to 15% of reproductive-age women worldwide, depending on the diagnostic criteria used. Accordingly, PCOS-associated dysglycemia and obesity are a global public health risk. Despite the public health importance of PCOS, notable gaps exist in the literature regarding its pathophysiology, natural history, and optimal management.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
Polycystic ovary syndrome (PCOS) is a complex endocrine condition that represents a lifelong health concern for 1 in 10 women worldwide.1 PCOS is commonly diagnosed by the presence of ovulatory dysfunction, androgen excess, and/or ovaries with polycystic morphology on ultrasound examination.2 Half of patients experience overweight or obesity.3 Most are at increased risk for serious comorbidities, including infertility, pregnancy complications (eg, gestational diabetes mellitus), impaired glucose tolerance, insulin resistance, type 2 diabetes mellitus, cardiovascular disease, gynecological cancers, anxiety, depression, eati...
Source: Journal of the American Dietetic Association - Category: Nutrition Authors: Tags: Research Source Type: research
Although we all know that>50% of the women that we care for are overweight or obese, these numbers cannot be over emphasized (1). At present, overweight and obesity are the most common diseases seen in our patients, and these conditions are less well studied than most other diagnoses, such as polycystic ovary syndrome (PCOS), recurrent pregnancy loss, and thyroid dysfunction. Although many studies have focused their primary objective on the association between body mass index (BMI) and reproductive outcomes (i.e., obesity increases the risk of miscarriage or obesity lowers pregnancy rates [PRs]), there are rare studies ...
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
Abstract Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among reproductive-aged women. While PCOS is associated with an increased risk of obesity and insulin resistance, little is known regarding the prevalence of and risk factors for nonalcoholic fatty liver disease (NAFLD) among Japanese women with PCOS. We estimated the prevalence of and risk factors for elevated liver enzymes, as the index of NAFLD, in Japanese women with PCOS. Methods: We retrospectively reviewed 102 reproductive-aged women who visited the Department of Gynecology, Kyoto Medical Center in Japan from January 2...
Source: Clin Med Res - Category: Research Authors: Tags: J Clin Med Res Source Type: research
ez CM Abstract Pregnancy hypertensive disorders such as preeclampsia (PE) are strongly correlated with insulin resistance, a condition in which the metabolic handling of D-glucose is deficient. In addition, the impact of preeclampsia is enhanced by other insulin resistant disorders, including polycystic ovary syndrome and obesity. For this reason, there is a clear association among maternal insulin resistance, polycystic ovary syndrome, obesity and the development of PE. However, whether PE is a consequence or the cause of these disorders is still unclear. Insulin therapy is usually recommended to pregnant women w...
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research
Abstract Polycystic ovary syndrome (PCOS) is the most common metabolic and endocrine disorder in women, leading to infertility. However, there is no general agreement concerning how to diagnose and treat PCOS. The Rotterdam consensus statement from the European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine, the Chinese diagnostic criteria and consensus statement, and the clinical practice guideline from the Endocrine Society in the USA are widely recognized. Guidance has been provided for clinical practice based on a comparative analysis of the above three practice guideli...
Source: J Zhejiang Univ Sci ... - Category: Science Authors: Tags: J Zhejiang Univ Sci B Source Type: research
Abstract BACKGROUND: Letrozole is widely employed as ovulation induction agent in women with PCOS, but its use in mild stimulation (MS) protocols for IVF is limited. Aim of the present study was to evaluate the feasibility of a MS protocol with letrozole plus hMG in non-obese PCOS women undergoing IVF after a metformin pre-treatment. METHODS: We retrospectively evaluated the data of 125 non-obese PCOS undergoing MS with letrozole plus hMG, 150 IU as starting dose, (group 1, N = 80) compared to those undergoing a conventional IVF stimulation protocols (CS) (group 2, N = 45) pri...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
One of the commonest questions which patients ask me is - What ispolycystic ovariandisease (or PCO, also known as PCOD and PCOS? ) And what are its risks ?This has now become a very common diagnosis, and is made by gynecologists, dietitians, skin specialists and GPs as well. The diagnosis is made typically for young girls, who are worried because they irregular periods; are a little bit overweight; or have acne or some oily skin. Doctors order a panel of expensive blood tests ( which measure hormones levels such as FSH, LH, DHEA, testosterone and AMH), and these often turn out to be abnormal in these girls.The problem...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
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