Diarrhea and Constipation as Cancer Treatment Side
Diarrhea and Constipation as Cancer Treatment Side Effects
CONCLUSION: The epidemic of opioid misuse has shown that there is a lack of fundamental knowledge about the characteristics and management of chronic pain, that conflicts of interest and validity of models must be more intensively considered in the context of drug development and that novel analgesics with less addictive potential are urgently needed. Currently, the most promising perspectives appear to be augmenting endogenous opioid actions and the selective activation of peripheral opioid receptors. PMID: 30645691 [PubMed - as supplied by publisher]
Condition: Opioid-induced Constipation in Patients With Cancer Interventions: Other: Electroacupuncture group; Other: Sham electroacupuncture group Sponsor: Guang'anmen Hospital of China Academy of Chinese Medical Sciences Not yet recruiting
ConclusionThe coix seed oil injection effectively reduced the pain level of cancer patients, significantly improved their life quality, and had no obvious adverse effects.
Conclusions Ontuxizumab, up to a dosage of 12 mg/kg weekly, was generally safe and well tolerated in this population, with no dose-limiting toxicities. The maximum tolerated dose was not reached; 8 mg/kg weekly or 12 mg/kg biweekly were the recommended dosages. We observed long-term disease stabilization in GC and extraskeletal chondrosarco ma, and tumor shrinkage in gastrointestinal stromal tumor and HCC.Trial registration: NCT01773434 (ClinicalTrials.gov).
This is the first meta ‐analysis to compare nivolumab and docetaxel‐based chemotherapy in advanced non‐small cell lung cancer (NSCLC) patients. Nivolumab was overall better than docetaxel‐based chemotherapy for advanced NSCLC in both anti‐tumor efficacy and safety. Based on our analysis of related literatures, N CCN guidelines for lung cancer and combined with our results, we suggest that 10% might be a suitable cutoff value of PD‐L1 expression for nivolumab treatment in NSCLC patients. AbstractBackgroundAs an inhibitor of programmed death ‐1 (PD‐1) protein, nivolumab has been shown to be effective in vario...
This report presents key information on the basis for Food and Drug Administration approval of pembrolizumab for the treatment of patients with locally advanced or metastatic gastric or GEJ adenocarcinoma whose tumors express PD‐L1. The report discusses the basis for limiting the indication to patients with PD‐L1‐expressing tumors and the basis for recommending that PD‐L1 status be assessed using a fresh tumor specimen if PD‐L1 expression is not detected in an archival gastric or GEJ cancer specimen.
ConclusionsThe in vitro studies and in vivo models have provided a simple bio-scientific justification for various ethnopharmacological uses of Psoralea species. From the toxicological perspective, the root, leaf, and seed extracts and their preparations have been proven to be safe when consumed in the recommended doses. But, meticulous studies on the pharmaceutical standardization, mode of action of the active constituents, and sustainable conservation of Psoralea species are needed, to meet the growing demands of the pharmaceutical industries, and to fully exploit their preventive and therapeutic potentials.
ConclusionNausea was a common symptom in this patient population and many different etiologies were suggested. Most patients reported a lower degree of nausea at follow-up. More research in treatment approaches and specific antiemetics is strongly needed.
This study was performed to evaluate effects of education, home visits, web, and phone counseling on chemotherapy symptoms and anxiety in patients with colorectal cancer receiving chemotherapy. This pretest-posttest, quasi-experimental study was conducted in a chemotherapy unit of a hospital between February 2014 and October 2015. Due to dropouts from the study, was completed on 51 participants in the control group and 31 participants in the experimental group. The experimental group was offered a program that includes home visit, nursing education, web counseling, and tele-counseling (HEWCOT), developed by the researchers...
Conclusion: LC chemotherapy has a high prevalence of AEs. However, the majority are low grade recovering with need-based SCMs, without any need for hospitalization.