Synthesis, characterization and cancer cell growth inhibition activity of ruthenium(II) complexes bearing bidentate pyrrole-imine ligands

Publication date: 1 August 2018 Source:Journal of Organometallic Chemistry, Volume 868 Author(s): Guan-Hao Chen, Wohn-Jenn Leu, Jih-Hwa Guh, Chia-Her Lin, Jui-Hsien Huang A series of bidentate pyrrole-imine ligands, [C4H3NH-(2-CH=N-R)] (1, R = cyclohexenyl; 2, R = CH2CH2-1-cyclohexenyl; 3, R =  t Bu; 4, R = CH2-2-furyl; 5, R = 2-methoxylphenyl; 6, R = phenyl; 7, R = 3-nitrophenyl; 8, R = 2,6-di-isopropylphenyl; 9, R = 2,4,6-trimethylphenyl), were synthesized and their corresponding ruthenium metal compounds {Ru (ɳ 6 -p-cymene)[C4H3N-(2-CH=N-R)]Cl} (Ru-1∼Ru-9) were also synthesized. These ligands and ruthenium compounds were all characterized by 1H and 13C NMR spectroscopy and some of their structures are also determined by single crystal X-ray crystallography. The Ru-1∼Ru-9 showed excellent GI 50 for PC-3 and DU-145 with the range of 3.83–12.13 and 4.25–11.22 μM, respectively. Among of these ruthenium compounds, Ru-6 has the best activity indicating phenyl ring is the key group on the imine substituents of these ruthenium compounds. Graphical abstract
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research