A new class of well-defined ruthenium catalysts for enantioselective transfer hydrogenation of various ketones

Publication date: 15 August 2018 Source:Journal of Organometallic Chemistry, Volume 869 Author(s): Cezmi Kayan, Nermin Meriç, Khadichakhan Rafikova, Alexey Zazybin, Nevin Gürbüz, Mehmet Karakaplan, Murat Aydemir A pair of novel optically pure phosphinite ligands were synthesized by ring opening reaction of chiral amines with (R)-styrene oxide or (S)-glycidyl phenyl ether oxide using a straightforward method in high yields and their ruthenium complexes were described in detail. The ruthenium complexes proved to be highly efficient catalysts for the enantioselective hydrogenation of ketones, affording products up to 99% ee. The results showed that the corresponding chiral alcohols could be obtained with high activity and excellent enantioselectivities at the desired temperature. (2S)-1-{benzyl[(1S)-1-(naphthalen-1-yl)ethyl]amino}-3-phenoxypropan-2-yl diphenylphosphinito[dichloro(η6-benzene)ruthenium (II)] acts an excellent catalyst in the reduction of ketones, giving the corresponding alcohol up to 99% ee. Graphical abstract

Source: Journal of Organometallic Chemistry - June 18, 2018 Category: Chemistry Source Type: research