Clinical utility of bone markers in various diseases

Measurements of bone markers (BMs) in peripheral blood or urine are a pivotal part of bone research within modern clinical medicine. In recent years the use of BMs increased substantially as they can be useful either to diagnose bone (related) disease and to follow its natural history, but also to monitor the effects of interventions. However, the use of BMs is still complicated mainly due to (pre)analytical variability of these substances, limited accessibility of assays, variable cut-off values in different countries and laboratories and heterogeneous results with regard to clinical implications of measuring BMs in several studies.

Source: Bone - June 16, 2018 Category: Orthopaedics Authors: M.C. Vlot, M. den Heijer, R.T. de Jongh, M.G. Vervloet, W.F. Lems, R. de Jonge, B. Obermayer-Pietsch, A.C. Heijboer Tags: Review Article Source Type: research