Reply to the Editor — Flecainide and Propafenone: Good Twins for Premature Ventricular Contractions’ Killing But Not Exactly Superimposable

We thank Capucci et  al for their thoughtful comments. We agree that mean doses of flecainide (88.5 ± 11.3 mg twice daily) and propafenone (extended release: 291.7 ± 19.5 mg twice daily; 1 patient immediate release: 150 mg thrice daily) were low. Despite this, mean premature ventricular contraction (PVC) burden decr eased by>72%. It is possible that higher doses of class IC antiarrhythmic drugs would have resulted in even greater efficacy. Capucci et  al also make an important point regarding the high rate of concomitant β-blocker use (90%).

Source: Heart Rhythm - June 8, 2018 Category: Cardiology Authors: David S. Frankel Source Type: research