Vascular calcification : from pathophysiology to biomarkers.

Vascular calcification : from pathophysiology to biomarkers. Clin Chim Acta. 2014 Sep 15; Authors: Evrard S, Delanaye P, Kamel S, Cristol JP, Cavalier E, SFBC/SN joined working group on vascular calcifications, SFBC/SN joined working group on vascular calcifications Abstract The link between vascular calcification (VC) and increased mortality is now well established. Over time, as clinical importance of this phenomenon has begun to be fully considered, scientists have highlighted more and more physiopathological mechanisms and signaling pathways that underlie VC. Several conditions such as diabetes, dyslipidemia and renal diseases are undoubtelly identified as predisposing factors. But even if the process is better understood, many questions still remain unanswered. This review briefly develops the various theories that attempt to explain mineralization genesis. Nonetheless, the main purpose of the article is to provide a profile of the various existing biomarkers of VC. Indeed, in the past years, a lot of inhibitors and promoters, which form a dense and interconnected network, were identified. Given importance to assess and control mineralization process, a focusing on accumulated knowledge of each marker seemed to be necessary. Therefore, we tried to define their respective role in the physiopathology and how they can contribute to calcification risk assessment. Among these, Klotho / fibroblast growth factor-23, fetuin-A, Matrix Gl...
Source: International Journal of Clinical Chemistry - Category: Chemistry Authors: Tags: Clin Chim Acta Source Type: research