Kidney dysfunction in the low birth weight murine adult: implications of oxidative stress.

In conclusion, despite some minor differences, LBW female and male adults that have a reduced nephron endowment experience comparable progressive renal and vascular dysfunction that is associated with increased oxidative stress and subsequent endothelial dysfunction. Tempol treatment and/or NOX4 inhibition attenuates renal and vascular dysfunction in LBW adults.
PMID: 29846114 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - May 30, 2018 Category: Urology & Nephrology Authors: Abdulmahdi W, Rabadi MM, Jules E, Marghani Y, Marji N, Leung J, Zhang FF, Siani A, Siskind T, Vedovino K, Chowdhury N, Sekulic M, Ratliff BB Tags: Am J Physiol Renal Physiol Source Type: research