Nipah virus death toll rises to 15, two new cases found in India's Kerala

KOCHI/MUMBAI (Reuters) - Two new cases of the deadly brain-damaging Nipah virus have been confirmed in the southern Indian state of Kerala, where another two people were killed by the virus, a health official said on Thursday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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Authors: Ochani RK, Batra S, Shaikh A, Asad A Abstract The Nipah virus was discovered twenty years ago, and there is considerable information available regarding the specificities surrounding this virus such as transmission, pathogenesis and genome. Belonging to the Henipavirus genus, this virus can cause fever, encephalitis and respiratory disorders. The first cases were reported in Malaysia and Singapore in 1998, when affected individuals presented with severe febrile encephalitis. Since then, much has been identified about this virus. These single-stranded RNA viruses gain entry into target cells via a process k...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
by Neeltje van Doremalen, Teresa Lambe, Sarah Sebastian, Trenton Bushmaker, Robert Fischer, Friederike Feldmann, Elaine Haddock, Michael Letko, Victoria A. Avanzato, Ilona Rissanen, Rachel LaCasse, Dana Scott, Thomas A. Bowden, Sarah Gilbert, Vincent Munster Nipah virus (NiV) is a highly pathogenic re-emerging virus that causes outbreaks in South East Asia. Currently, no approved and licensed vaccine or antivirals exist. Here, we investigated the efficacy of ChAdOx1 NiVB, a simian adenovirus-based vaccine encoding NiV glycoprotein (G) Bangladesh, in Syrian hamsters. Prime-only as well as prime-boost vaccination resulted i...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
India has put more than 300 people under surveillance after a 23-year-old man was diagnosed with the Nipah virus, a rare and often deadly disease.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
In this study, intermediate-size aerosol particles (~7 μm) of NiV-Malaysia were used to mimic potential routes of exposure by focusing viral deposition in the upper respiratory tract. Our previous report showed this route of exposure extended the disease course and a single animal survived the infection. Here, analysis of the peripheral immune response found minimal evidence of systemic inflammation and depletion of B cells during acute disease. However, the animal that survived infection developed an ear ly IgM response with rapid development of neutralizing antibodies that likely afforded protection. The increase in N...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
The deadly brain-damaging Nipah virus has resurfaced in the southern Indian state of Kerala a year after it killed 17 people, state officials said on Tuesday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
In conclusion, the etiology could not be found in 77% of the samples, indicating that the commercial PCR panels used are not suitable in this setting. Future studies on the etiology of CNS infections in Nepal could include metagenomic techniques. PMID: 31162021 [PubMed - as supplied by publisher]
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Nipah virus is listed as one of the World Health Organization's priority pathogens, meaning urgent action is needed against it.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
African green monkeys survived infection with the Nipah virus after they received remdesivir. The virus, a pandemic threat carried by bats, has killed dozens of people in Asia.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Nipah Virus Ebola Virus Bats MERS (Middle East Respiratory Syndrome) Epidemics National Institute of Allergy and Infectious Diseases Gilead Sciences Inc Science Translational Medicine (Journal) Bangladesh Malaysia India Source Type: news
Nipah virus can cause neurological and respiratory disease; the mortality rate is about 70%.
Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news
Nipah virus is an emerging pathogen in the Paramyxoviridae family. Upon transmission of Nipah virus from its natural reservoir, Pteropus spp. fruit bats, to humans, it causes respiratory and neurological disease with a case-fatality rate about 70%. Human-to-human transmission has been observed during Nipah virus outbreaks in Bangladesh and India. A therapeutic treatment for Nipah virus disease is urgently needed. Here, we tested the efficacy of remdesivir (GS-5734), a broad-acting antiviral nucleotide prodrug, against Nipah virus Bangladesh genotype in African green monkeys. Animals were inoculated with a lethal dose of Ni...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Reports Source Type: research
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