Monophasic Synovial Sarcoma of Tongue: A Rarest of Rare Case Scenario

AbstractSynovial sarcoma is a rare tumour of head and neck. Primary synovial sarcoma of tongue is very uncommon. Based on morphology, it can be classified as classical biphasic variant, monophasic spindle cell variant, monophasic epithelial variant and poorly differentiated variant. The authors with an index case of 74  year old lady with monophasic spindle cell synovial sarcoma of oral tongue which is one of the rarest variants (our case is the 15th case reported of synovial sarcoma of the tongue and only the 3rd case in the world which had a monophasic histopathologic pattern) studied the morphology and describ ed the disease entity in detail. She was treated with wide local excision of sarcoma followed by adjuvant radiotherapy.
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research

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Journal of Cardiac Surgery, EarlyView.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: IMAGES IN CARDIAC SURGERY Source Type: research
In conclusion, 5-HTR1B, 5-HTR2B, DRD1, and DRD2 show mRNA overexpression in a broad spectrum of common and rare cancers. 5-HTR2B protein is frequently highly expressed in human cancers, especially on endothelial cells. These findings support further investigation of especially 5HTR2B as a potential treatment target. PMID: 31478179 [PubMed - as supplied by publisher]
Source: Pathology Oncology Research - Category: Pathology Authors: Tags: Pathol Oncol Res Source Type: research
Conclusion: While we were unable to find a significant difference in outcomes or amputation rates between those who underwent reexcision of a previously unplanned excision and those who underwent an initial planned resection, the high rate of unplanned excision is troubling and should remind practitioners to consider sarcoma in the differential of all upper extremity masses. PMID: 31467480 [PubMed]
Source: Sarcoma - Category: Cancer & Oncology Tags: Sarcoma Source Type: research
Conclusion: Only complete resection of the tumor seems to be an independent prognostic factor. To our knowledge, this is the first report on the safety and effectivity of pazopanib in PSS and may provide guidance for similar cases in the future.
Source: In Vivo - Category: Research Authors: Tags: Clinical Studies Source Type: research
AbstractT cell receptor (TCR) gene-engineered T cells have shown promise in the treatment of melanoma and synovial cell sarcoma, but their application to epithelial cancers has been limited. The identification of novel therapeutic TCRs for the targeting of these tumors is important for the development of new treatments. Here, we describe the preclinical characterization of a TCR directed against Kita-Kyushu Lung Cancer Antigen-1 (KK-LC-1, encoded byCT83), a cancer germline antigen with frequent expression in human epithelial malignancies including gastric cancer, breast cancer, and lung cancer. Gene-engineered T cells expr...
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Shohei Matsuo, Emiko Tomita, Kenjiro Fukuhara, Akinori Akashi, Yoshitane TsukamotoAbstractWe experienced two cases of poorly differentiated synovial sarcoma (PDSS) arising from the chest wall. The first 42-year-old female patient was asymptomatic, but incidental chest roentgenogram showed a chest wall mass about 5-cm in maximal diameter with extrapleural sign. The chest wall mass was removed at other hospital. A tentative pathological diagnosis was mesothelioma with small cell features. After several courses of chemotherapy consisting...
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
ConclusionThe survival of patients with  CSS is positively influenced by a young patient's age and greatly improved by the administration of chemotherapy, even in the absence of tumor resection.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: REVIEW ARTICLE Source Type: research
Abstract: Synovial sarcoma (SS) is a high-grade soft-tissue sarcoma occurring predominantly in older children and young adults. Only approximately 7% occur in the head and neck region, with SS representing less than 0.1% of all head and neck cancers. Orbital location is exceedingly rare with only 8 cases reported so far in the literature. It is noted for its propensity for late local recurrences and metastases. Histologically, SS is monophasic, biphasic, or poorly differentiated and harbors a specific chromosomal translocation t(X;18)(p11.2;q11.2) in>95% of cases. In this article, we describe a case of monophasic SS p...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Brief Report Source Type: research
Introduction: Synovial sarcomas are an aggressive type of sarcoma, constituting approximately 10% of all soft tissue sarcomas. They are most common on the extremities with a mean age of 30 years at diagnosis. Although synovial sarcomas are typically localized at the time of diagnosis, they metastasize more frequently than other soft tissue sarcomas to the lungs, lymph nodes and bone.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
ConclusionsAt a tertiary musculoskeletal oncology referral clinic, primary STMs ≤ 2 cm with indeterminate imaging features should be managed cautiously despite their small size and/or superficial location.
Source: Skeletal Radiology - Category: Radiology Source Type: research
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