Treatment of hepatitis C virus infection in patients with mixed cryoglobulinemic syndrome and cryoglobulinemic glomerulonephritis

Hemodialysis International,Volume 22, Issue S1, Page S81-S96, April 2018.
Source: Hemodialysis International - Category: Hematology Authors: Source Type: research

Related Links:

Abstract Cryoglobulinemia is a rare cause of kidney disease that occurs in patients with various diseases. Renal involvement often occurs after appearance of various clinical manifestations dominated by purpura and neuropathy. The aim of this study is to describe clinical, biological, and pathological characteristics of cryoglobulinemic glomerulonephritis (GN), as well as treatment and outcome. This is a retrospective study including all patients with positive cryoglobulin test and biopsy-proven GN secondary to cryoglobulinemia. Fourteen patients with cryoglobulinemic GN were collected. Their mean age was 46.92 &p...
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research
Hepatitis C virus (HCV) infection is a major cause of viral hepatitis with a global seroprevalence estimated to be greater than 185 million [1]. Approximately 75% to 85% of patients with HCV infection develop a chronic hepatitis C (CHC) infection [2]. In addition to the direct negative impact by the virus on the liver, where more than 40% of CHC infections leads to liver cirrhosis after 30 years [3], CHC infection is also associated with extrahepatic manifestations including kidney disease, most commonly membranoproliferative glomerulonephritis with or without cryoglobulinemia [4].
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Hepatitis C virus (HCV) infection is a major cause of viral hepatitis with a global seroprevalence estimated to be greater than 185 million.1 Approximately 75% to 85% of patients with HCV infection develop a chronic hepatitis C (CHC) infection.2 In addition to the direct negative impact of the virus on the liver, where more than 40% of CHC infections lead to liver cirrhosis after 30  years,3 CHC infection is also associated with extrahepatic manifestations including kidney disease, most commonly membranoproliferative glomerulonephritis with or without cryoglobulinemia.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Research Article Source Type: research
Abstract Acute kidney injury (AKI) is common in hospitalized patients with mortality varying from 10% to 80%. It is crucial to know the incidence and etiology of AKI to promote prevention strategies. Our study aimed at obtaining a comprehensive review of the pattern and spectrum of patients who presented for emergency hemodialysis to Kasr Al-Aini Hospital between October 2012 and October 2014. We analyzed clinical and laboratory factors in all such patients. Two thousand twenty three patients were included of which patients with AKI were 728 patients (36%). Cardiac diseases were the cause of AKI in 171 patients, o...
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research
We present a case of spontaneous intraperitoneal hemorrhage, an unexpectedly severe complication of cocaine-related ANCA vasculitis, developing late during hospitalization. Case Report: An adult male with a history of hepatitis C, distant cocaine use, and limited health care presented to a local emergency department (ED) with volume overload, renal failure, hyperkalemia and non-anion gap metabolic acidosis. An extensive workup ensued, followed by pulse-dose methylprednisolone and plasma exchange for ANCA vasculitis with crescentic glomerulonephritis. Tachycardia and hypertension persisted throughout hospitalization despit...
Source: Journal of Addiction Medicine - Category: Addiction Tags: Case Reports Source Type: research
CONCLUSION: According to this study, fibrillary glomerulonephritis represents a secondary glomerular disease process (associated with autoimmune disease, infection or malignancy) in many cases and hence screening is essential. As the screening for comorbidities increased over time, more underlying causes were identified. We noted a high frequency of HCV among black patients, suggesting a possible causative association. Treatment of underlying disease is essential for patients for the best outcome. PMID: 28161700 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: Am J Nephrol Source Type: research
Conclusion: According to this study, fibrillary glomerulonephritis represents a secondary glomerular disease process (associated with autoimmune disease, infection or malignancy) in many cases and hence screening is essential. As the screening for comorbidities increased over time, more underlying causes were identified. We noted a high frequency of HCV among black patients, suggesting a possible causative association. Treatment of underlying disease is essential for patients for the best outcome.Am J Nephrol 2017;45:248-256
Source: American Journal of Nephrology - Category: Neurology Source Type: research
We report the case of a 63‐year‐old female HCV‐positive renal transplant patient with biopsy‐proven recurrence of MPGN in the renal graft 3 years after transplant. Because of rapid loss of transplant function and consecutive need for hemodialysis, we initiated a combined anti‐HCV–directed therapy regimen consisting of daclatasvir and simeprevir over 12 weeks. Viral clearance of HCV was obtained as early as 2 weeks after start of treatment. No adverse therapy‐associated side effects were observed, and immunosuppressive dosing remained unchanged. Importantly, graft function fully recovered and hemodialysis ...
Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Tags: Case Report Source Type: research
Hepatitis C virus (HCV) infection is associated with tremendous morbidity and mortality due to liver complications. HCV infection is also associated with many extrahepatic manifestations including cardiovascular diseases, glucose metabolism impairment, cryoglobulinemia vasculitis, B cell non-Hodgkin lymphoma and chronic kidney disease (CKD). Many studies have shown a strong association between HCV and CKD, by reporting (i) an increased prevalence of HCV infection in patients on haemodialysis, (ii) an increased incidence of CKD and proteinuria in HCV-infected patients, and (iii) the development of membranoproliferative glom...
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Review Source Type: research
ra CS Abstract The study aimed to estimate the incidence of HCV seroconversion in hemodialysis patients in the Brazilian Unified National Health System (SUS). This was a prospective, non-concurrent study using patients' data identified by deterministic and probabilistic record linkage in the SUS information system. The study included 47,079 patients started on hemodialysis between January 1, 2000, and December 31, 2003, followed until seroconversion or conclusion of the study in 2004. Three percent of hemodialysis patients HCV-seroconverted (1.7 per 100 patient-years). Increased risk of HCV seroconversion was asso...
Source: Cadernos de Saude Publica - Category: Global & Universal Authors: Tags: Cad Saude Publica Source Type: research
More News: Dialysis | Glomerulonephritis | Hematology | Hemodialysis | Hepatitis | Hepatitis C