Global Maps of ProQ Binding In  Vivo Reveal Target Recognition via RNA Structure and Stability Control at mRNA 3′ Ends

Using CLIP-seq, Holmqvist et  al. map transcriptome-wide interactions of the emerging global RNA-binding protein ProQ in Salmonella and E. coli. Their data suggest ProQ to target sRNAs and mRNA 3′ UTRs primarily through a structural code and to stabilize some mRNAs by counteracting 3′ exoribonuclease activity.

Source: Molecular Cell - May 24, 2018 Category: Cytology Authors: Erik Holmqvist, Lei Li, Thorsten Bischler, Lars Barquist, J örg Vogel Tags: Resource Source Type: research