Development and biological validation of a cyclic stretch culture system for the ex vivo engineering of tendons.

CONCLUSION: We designed a pulsatile strain bioreactor for tendon tissue engineering. The in vitro characterization shows a preferential cell alignment at short time points. Prolonged culture time, however, seems to influence negatively on the survival of the cells indicating the need of further optimization concerning the culture conditions and the mechanical stimulation.
PMID: 29781355 [PubMed - as supplied by publisher]

Source: The International Journal of Artificial Organs - May 1, 2018 Category: Transplant Surgery Authors: Raimondi MT, Laganà M, Conci C, Crestani M, Di Giancamillo A, Gervaso F, Deponti D, Boschetti F, Nava MM, Scandone C, Domeneghini C, Sannino A, Peretti GM Tags: Int J Artif Organs Source Type: research