Nanogels as potential drug nanocarriers for CNS drug delivery.

Nanogels as potential drug nanocarriers for CNS drug delivery.
Drug Discov Today. 2018 May 15;:
Authors: Vashist A, Kaushik A, Vashist A, Bala J, Nikkhah-Moshaie R, Sagar V, Nair M
Abstract
Hydrogel-based drug delivery systems (DDSs) have versatile applications such, as tissue engineering, scaffolds, drug delivery, and regenerative medicines. The drawback of higher size and poor stability in such DDSs are being addressed by developing nano-sized hydrogel particles, known as nanogels, to achieve the desired biocompatibility and encapsulation efficiency for better efficacy than conventional bulk hydrogels. In this review, we describe advances in the development of nanogels and their promotion as nanocarriers to deliver therapeutic agents to the central nervous system (CNS). We also discuss the challenges, possible solutions, and future prospects for the use of nanogel-based DDSs for CNS therapies.
PMID: 29775669 [PubMed - as supplied by publisher]

Source: Drug Discovery Today - May 15, 2018 Category: Drugs & Pharmacology Authors: Vashist A, Kaushik A, Vashist A, Bala J, Nikkhah-Moshaie R, Sagar V, Nair M Tags: Drug Discov Today Source Type: research