Loss of p21-activated kinase 1 (Pak1) promotes atrial arrhythmic activity

Atrial fibrillation (AF) is initiated through arrhythmic atrial excitation from outside the sinus node or remodeling of atrial tissue that allows reentry of excitation. Angiotensin II (AngII) has been implicated in the initiation and maintenance of AF through changes in Ca2+ handling and production of reactive oxygen species (ROS).

Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: Jaime DeSantiago, Dan J. Bare, Disha Varma, R. John Solaro, Rishi Arora, Kathrin Banach Source Type: research