Enantioselective nickel-catalyzed arylative intramolecular 1,4-allylations.

Enantioselective nickel-catalyzed arylative intramolecular 1,4-allylations.
Chem Commun (Camb). 2018 May 17;:
Authors: Nguyen TLN, Incerti-Pradillos CA, Lewis W, Lam HW
Abstract
The enantioselective nickel-catalyzed desymmetrization of allenyl cyclohexa-2,5-dienones by reaction with arylboronic acids is described. Nickel-catalyzed arylation of the allene gives allylnickel species, which undergo cyclization by 1,4-allylation to produce hexahydroindol-5-ones and hexahydrobenzofuran-5-ones with three contiguous stereocenters in high diastereo- and enantioselectivities.
PMID: 29770399 [PubMed - as supplied by publisher]

Source: Chemical Communications - May 17, 2018 Category: Chemistry Authors: Nguyen TLN, Incerti-Pradillos CA, Lewis W, Lam HW Tags: Chem Commun (Camb) Source Type: research